Document Detail


Heparanase overexpression participates in tumor growth of cervical cancer in vitro and in vivo.
MedLine Citation:
PMID:  23288725     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Expression of heparanase is associated with invasion, metastasis and angiogenesis of a variety of human cancers. However, the roles of heparanase in cervical cancer are not clear. The aim of this study is to determine whether up-regulation of heparanase expression can promote growth of cervical cancer in vitro and in vivo. Heparanase protein expression was analyzed in cervical cancer patients using immunohistochemistry. In addition, expression of heparanase was also examined in cervical cancer cell lines. A series of in vivo and in vitro assays was performed to elucidate the role of heparanase in tumor growth of cervical cancer. Positive rate of heparanase was 63.3 % (38/60) in cervical cancer patients by immunohistochemistry, and it was significantly correlated with tumor size and clinical stage (P < 0.05). Overexpression of heparanase inhibited apoptosis of cervical cancer cells. Moreover, ectopic overexpression of heparanase in cervical cancer cells promoted proliferation of cervical cancer cells in vitro and tumor growth in vivo. These results suggest that heparanase participates in tumor growth of cervical cancer by influencing the proliferation and apoptosis of cervical cancer cells, and heparanase could be used as an effective therapeutic target for cervical cancer.
Authors:
Chao Zeng; Zun-Fu Ke; Wei-Ren Luo; Yun-Hong Yao; Xin-Rong Hu; Wei Jie; Jin-Bao Yin; Shi-Jun Sun
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Publication Detail:
Type:  Journal Article     Date:  2013-01-04
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403     Citation Subset:  IM    
Affiliation:
Department of Pathology, Guangdong Medical College, Dongguan, 523808, China, zengchaosysu@126.com.
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