Document Detail


Heparan sulphate: a heparin in miniature.
MedLine Citation:
PMID:  22566232     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Heparan sulphate (HS), discovered in 1948 in heparin by-products, only emerged slowly from the shadow of heparin. Its inauspicious beginning was followed by the gradual realisation that HS was a separate entity with distinctive features. Both HS and heparin follow a common biosynthetic route but while heparin reaches full maturity, HS holds on to some of its youthful traits. The novel design and complex patterning of sulphation in HS enable it fulfil key roles in many, diverse biological processes.
Authors:
J T Gallagher
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Handbook of experimental pharmacology     Volume:  -     ISSN:  0171-2004     ISO Abbreviation:  Handb Exp Pharmacol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902231     Medline TA:  Handb Exp Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  347-60     Citation Subset:  IM    
Affiliation:
Paterson Institute for Cancer Research, Iduron Ltd., University of Manchester, Manchester, M20 4BX, UK, jgallagher@picr.man.ac.uk.
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