| Heparan sulphate: a heparin in miniature. | |
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MedLine Citation:
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PMID: 22566232 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Heparan sulphate (HS), discovered in 1948 in heparin by-products, only emerged slowly from the shadow of heparin. Its inauspicious beginning was followed by the gradual realisation that HS was a separate entity with distinctive features. Both HS and heparin follow a common biosynthetic route but while heparin reaches full maturity, HS holds on to some of its youthful traits. The novel design and complex patterning of sulphation in HS enable it fulfil key roles in many, diverse biological processes. |
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Authors:
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J T Gallagher |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-05-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 347-60 Citation Subset: IM |
Affiliation:
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Paterson Institute for Cancer Research, Iduron Ltd., University of Manchester, Manchester, M20 4BX, UK, jgallagher@picr.man.ac.uk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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