Document Detail

The heparan and heparin metabolism pathway is involved in regulation of fatty acid composition.
MedLine Citation:
PMID:  21647334     Owner:  NLM     Status:  MEDLINE    
Six genes involved in the heparan sulfate and heparin metabolism pathway, DSEL (dermatan sulfate epimerase-like), EXTL1 (exostoses (multiple)-like 1), HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), HS6ST3 (heparan sulfate 6-O-sulfotransferase 3), NDST3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3), and SULT1A1 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), were investigated for their associations with muscle lipid composition using cattle as a model organism. Nineteen single nucleotide polymorphisms (SNPs)/multiple nucleotide length polymorphisms (MNLPs) were identified in five of these six genes. Six of these mutations were then genotyped on 246 Wagyu x Limousin F(2) animals, which were measured for 5 carcass, 6 eating quality and 8 fatty acid composition traits. Association analysis revealed that DSEL, EXTL1 and HS6ST1 significantly affected two stearoyl-CoA desaturase activity indices, the amount of conjugated linoleic acid (CLA), and the relative amount of saturated fatty acids (SFA) and monounsaturated fatty acids (MUFA) in skeletal muscle (P<0.05). In particular, HS6ST1 joined our previously reported SCD1 and UQCRC1 genes to form a three gene network for one of the stearoyl-CoA desaturase activity indices. These results provide evidence that genes involved in heparan sulfate and heparin metabolism are also involved in regulation of lipid metabolism in bovine muscle. Whether the SNPs affected heparan sulfate proteoglycan structure is unknown and warrants further investigation.
Zhihua Jiang; Jennifer J Michal; Xiao-Lin Wu; Zengxiang Pan; Michael D MacNeil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-21
Journal Detail:
Title:  International journal of biological sciences     Volume:  7     ISSN:  1449-2288     ISO Abbreviation:  Int. J. Biol. Sci.     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-07     Completed Date:  2011-10-04     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101235568     Medline TA:  Int J Biol Sci     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  659-63     Citation Subset:  IM    
Department of Animal Sciences, Washington State University, Pullman, WA 99164-6351, USA.
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MeSH Terms
Fatty Acids / chemistry*,  genetics,  metabolism*
Heparin / genetics,  metabolism*
Heparitin Sulfate / genetics,  metabolism*
Muscles / metabolism
Polymorphism, Single Nucleotide / genetics
Reg. No./Substance:
0/Fatty Acids; 9005-49-6/Heparin; 9050-30-0/Heparitin Sulfate

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