| Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development. | |
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MedLine Citation:
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PMID: 12645923 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patterning of the ventral head has been attributed to various cell populations, including endoderm, mesoderm, and neural crest. Here, we provide evidence that head and heart development may be influenced by a ventral midline endodermal cell population. We show that the ventral midline endoderm of the foregut is generated directly from the extreme rostral portion of Hensen's node, the avian equivalent of the Spemann organizer. The endodermal cells extend caudally in the ventral midline from the prechordal plate during development of the foregut pocket. Thus, the prechordal plate appears as a mesendodermal pivot between the notochord and the ventral foregut midline. The elongating ventral midline endoderm delimits the right and left sides of the ventral foregut endoderm. Cells derived from the midline endoderm are incorporated into the endocardium and myocardium during closure of the foregut pocket and fusion of the bilateral heart primordia. Bilateral ablation of the endoderm flanking the midline at the level of the anterior intestinal portal leads to randomization of heart looping, suggesting that this endoderm is partitioned into right and left domains by the midline endoderm, thus performing a function similar to that of the notochord in maintaining left-right asymmetry. Because of its derivation from the dorsal organizer, its extent from the forebrain through the midline of the developing face and pharynx, and its participation in formation of a single midline heart tube, we propose that the ventral midline endoderm is ideally situated to function as a ventral organizer of the head and heart. |
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Authors:
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Margaret L Kirby; Aaron Lawson; Harriett A Stadt; Donna H Kumiski; Kathleen T Wallis; Eileen McCraney; Karen L Waldo; Yin-Xiong Li; Gary C Schoenwolf |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental biology Volume: 253 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-03-20 Completed Date: 2003-04-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 175-88 Citation Subset: IM |
Affiliation:
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Neonatal-Perinatal Research Institute, Division of Neonatology, Department of Pediatrics, Box 3179, Duke University Medical Center, Durham, NC 27710, USA. kirby013@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Carbocyanines Chick Embryo Chimera Coturnix Digestive System / embryology* Endoderm / cytology Gene Expression Regulation, Developmental Genes, Homeobox Head / embryology* Heart / embryology* Homeodomain Proteins / genetics Models, Biological Organizers, Embryonic / embryology* Rhodamines |
| Grant Support | |
ID/Acronym/Agency:
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DC 04185/DC/NIDCD NIH HHS; HD17063/HD/NICHD NIH HHS; HL36059/HL/NHLBI NIH HHS; NS18112/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/5-carboxytetramethylrhodamine succinimidyl ester; 0/Carbocyanines; 0/Homeodomain Proteins; 0/Rhodamines; 40957-95-7/3,3'-dioctadecylindocarbocyanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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