Document Detail

Henoch-Schönlein nephritis in children--a clinicopathological study.
MedLine Citation:
PMID:  4055236     Owner:  NLM     Status:  MEDLINE    
36 children with Henoch-Schönlein nephritis had their renal biopsy specimens studied by light and electron microscopic and immunofluorescence antibody techniques. Though no pathognomic changes were found the histological picture was characteristic. The severity of histological changes correlated well with the clinical manifestation and disease persistence. IMF studies showed characteristic mesangial IgA staining. The most prominent ultrastructural feature was segmental mesangial and subendothelial deposits with basement membrane changes. The amount of deposits was a good exponent of disease activity-children with few deposits recovering shortly. In spite of long duration, the outcome after an average 4 year follow-up was good, the majority of children having improved and renal insufficiency developing rarely. Renal biopsy is essential for an estimation of severity of renal disease and enables prognosis of disease persistence and long term outlook.
A M Zurowska; T Wrzolkowa; M Uszycka-Karcz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The International journal of pediatric nephrology     Volume:  6     ISSN:  0391-6510     ISO Abbreviation:  Int J Pediatr Nephrol     Publication Date:    1985 Jul-Sep
Date Detail:
Created Date:  1985-12-19     Completed Date:  1985-12-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007162     Medline TA:  Int J Pediatr Nephrol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
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MeSH Terms
Basement Membrane / pathology
Capillaries / pathology
Child, Preschool
Glomerular Mesangium / blood supply,  pathology
Glomerulonephritis / pathology*
Purpura, Schoenlein-Henoch / pathology*
Time Factors

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