| Henoch-Schönlein nephritis in children--a clinicopathological study. | |
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MedLine Citation:
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PMID: 4055236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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36 children with Henoch-Schönlein nephritis had their renal biopsy specimens studied by light and electron microscopic and immunofluorescence antibody techniques. Though no pathognomic changes were found the histological picture was characteristic. The severity of histological changes correlated well with the clinical manifestation and disease persistence. IMF studies showed characteristic mesangial IgA staining. The most prominent ultrastructural feature was segmental mesangial and subendothelial deposits with basement membrane changes. The amount of deposits was a good exponent of disease activity-children with few deposits recovering shortly. In spite of long duration, the outcome after an average 4 year follow-up was good, the majority of children having improved and renal insufficiency developing rarely. Renal biopsy is essential for an estimation of severity of renal disease and enables prognosis of disease persistence and long term outlook. |
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Authors:
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A M Zurowska; T Wrzolkowa; M Uszycka-Karcz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of pediatric nephrology Volume: 6 ISSN: 0391-6510 ISO Abbreviation: Int J Pediatr Nephrol Publication Date: 1985 Jul-Sep |
Date Detail:
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Created Date: 1985-12-19 Completed Date: 1985-12-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8007162 Medline TA: Int J Pediatr Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 183-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Basement Membrane / pathology Biopsy Capillaries / pathology Child Child, Preschool Female Glomerular Mesangium / blood supply, pathology Glomerulonephritis / pathology* Humans Male Purpura, Schoenlein-Henoch / pathology* Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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