Document Detail

Henoch-Schonlein purpura with high factor VIII levels and deep venous thrombosis: an association or coincidence?
MedLine Citation:
PMID:  18283464     Owner:  NLM     Status:  MEDLINE    
Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in children. Although long-term outcome is generally good, serious complications may occur. Thrombosis has been reported only as an extremely rare complication of HSP. Here, we describe a 15-year-old-boy with features of HSP, who developed left main iliac, external iliac and femoral vein thrombosis. Factor VIII (FVIII) and homocystein levels were found to be high. This suggests that HSP itself may lead to a prothrombotic state and increase the risk of developing thrombosis in patients who have any risk factors.
Rezan Topaloglu; Umut Selda Bayrakci; Barbaros Cil; Diclehan Orhon; Aysin Bakkaloglu
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2008-02-19
Journal Detail:
Title:  Rheumatology international     Volume:  28     ISSN:  0172-8172     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-06     Completed Date:  2009-01-27     Revised Date:  2009-07-29    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  935-7     Citation Subset:  IM    
Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
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MeSH Terms
Coagulation Protein Disorders / complications*
Factor VIII*
Femoral Vein / pathology
Iliac Vein / pathology*
Purpura, Schoenlein-Henoch / complications*
Venous Thrombosis / complications*
Reg. No./Substance:
9001-27-8/Factor VIII
Comment In:
Rheumatol Int. 2009 Aug;29(10):1251-2   [PMID:  19066898 ]

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