Document Detail

Henna (Lawsonia inermis Linn.) inducing haemolysis among G6PD-deficient newborns. A new clinical observation.
MedLine Citation:
PMID:  8985525     Owner:  NLM     Status:  MEDLINE    
Over a 10-year period, 15 glucose-6-phosphate dehydrogenase (G6PD)-deficient male newborns were admitted to Al-Jahra Hospital with acute haemolysis a few days after applying henna dye over the body, which is a unique Bedouin tribal practice to celebrate the arrival of the first-born boy. Laboratory investigations revealed significant anaemia, reticulocytosis and indirect hyperbilirubinaemia among the index newborns as compared with controls (p < 0.001). The mean (SD) haemoglobin concentration in index patients was 113.4 (13.4) g/l vs 171.2 (11.2) g/l in controls, reticulocytic count 13.8% (4.2%) vs 1.4% (0.74%), and indirect bilirubin 382.8 (58.7) mumol/l vs 63.7 (61.4) mumol/l. G6PD-deficient newborns with haemolysis linked to henna application had delayed age at presentation and a higher reticulocytic count and hyperbilirubinaemia compared with non-henna-induced haemolysis (p < 0.05). Percutaneous henna absorption is well recognized and clinical findings support the harmful effect of henna on G6PD-deficient red blood cells. A local health education programme has been established to prevent the use of henna dye in infancy.
H H Kandil; M M al-Ghanem; M A Sarwat; F S al-Thallab
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  16     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-19     Completed Date:  1997-03-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  IM    
Department of Paediatrics, Al-Jahra Hospital, Kuwait.
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MeSH Terms
Administration, Topical
Antifungal Agents / administration & dosage,  poisoning*
Glucosephosphate Dehydrogenase Deficiency / complications*
Hemolysis / drug effects*
Infant, Newborn
Medicine, Ayurvedic
Naphthoquinones / administration & dosage,  poisoning*
Skin Absorption
Reg. No./Substance:
0/Antifungal Agents; 0/Naphthoquinones; 83-72-7/lawsone

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