Document Detail

Hemoximetry as the "gold standard"? Error assessment based on differences among identical blood gas analyzer devices of five manufacturers.
MedLine Citation:
PMID:  18048894     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The calibration and testing procedures of a pulse oximeter with arterial blood samples from healthy subjects are based on reference values from the hemoximeter. There are no tests to identify the accuracy of the reference devices. Because of this limitation and since the true values of oxygen saturation (sO2 in %) in blood samples were not known, we used the differences between two identical devices, A and B, for error assessment. METHODS: Two identical devices, A and B, from five leading manufacturers were investigated. Seventy-two arterial blood samples from 12 healthy volunteers at three different levels of saturation between 100% and 70% sO2 were randomly evaluated by the test systems. RESULTS: The observed differences (Delta) between Devices A and B, as a measure for the error of the hemoximeters, increased significantly with all manufacturers from level 97 (Deltamin, -0.9%; Deltamax, 2.6%) to 85 (Deltamin, -2.4%; Deltamax, 4.3), this effect was even stronger between levels 97 and 75 (Deltamin, -4.6%; Deltamax, 4.3%). A variance proportion analysis revealed the concentration of the reduced hemoglobin as the main error source for sO2 measurements. Independent from the sO2 levels there were also significant differences for the carboxy hemoglobin concentration in the range of 0%-4% and for the methemoglobin concentration in the range of 0%-1%. CONCLUSIONS: The variance of sO2 measurements between identical devices increased significantly when saturation decreased from the normal level of 97% to the hypoxemic levels of 85% and 75%.
Hartmut Gehring; Lutz Duembgen; Mareike Peterlein; Söhnke Hagelberg; Leif Dibbelt
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  105     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-30     Completed Date:  2007-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S24-30, tables of contents     Citation Subset:  AIM; IM    
Department of Anesthesiology, University Clinic of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
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MeSH Terms
Anoxia / blood*
Carboxyhemoglobin / analysis
Equipment Design
Methemoglobin / analysis
Models, Cardiovascular
Observer Variation
Oximetry / instrumentation*,  standards
Oxygen / blood*
Oxyhemoglobins / analysis*
Reproducibility of Results
Reg. No./Substance:
0/Oxyhemoglobins; 7782-44-7/Oxygen; 9008-37-1/Methemoglobin; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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