Document Detail

Hemostatic treatment after tooth extraction in a patient with factor V deficiency.
MedLine Citation:
PMID:  9467366     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Factor V deficiency is a very rare hereditary coagulation disorder and tooth extraction in the patient with factor V deficiency has not been reported except in one case. PATIENTS AND TREATMENT: A 38-year-old woman with factor V deficiency was referred for extraction of the impacted lower third molar. After intravenous administration of frozen fresh plasma (FFP) and recognition of an increase of factor V level from 1-31%, upper and lower third molars were extracted. Eighteen and 48 h after the extraction, factor V was intermittently supplemented by injection of 4 and 2 units of FFP, respectively, and factor V was maintained above 12%. To form fast coagula and to protect the wound, the lower extraction socket was filled with a fibrin glue composed of factor XIII and fibrinogen (Beriplast P) and a plastic splint was applied. The wound was healed and epithelized within 2 weeks after the extraction without any bleeding or infectious consequences. CONCLUSION: Extraction in the patient with factor V hereditary deficiency is safely performed by both supplementation of factor V and application of local hemostasis.
T Yokoyama; Y Tatemoto; T Osaki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Oral diseases     Volume:  3     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-18     Completed Date:  1998-02-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  196-8     Citation Subset:  D    
Department of Oral Surgery, Kochi Medical School, Japan.
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MeSH Terms
Dental Care for Chronically Ill / methods*
Factor V Deficiency*
Fibrin Tissue Adhesive / therapeutic use
Hemostasis, Surgical*
Postoperative Hemorrhage / prevention & control
Tooth Extraction* / adverse effects
Reg. No./Substance:
0/Fibrin Tissue Adhesive

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