Document Detail

Hemostatic system as a risk factor for cardiovascular disease in women with subclinical hypothyroidism.
MedLine Citation:
PMID:  14611707     Owner:  NLM     Status:  MEDLINE    
Hypothyroidism has been associated with atherosclerosis. The mechanisms of atherosclerosis in patients with thyroid failure remain controversial. Hypofibrinolysis might be a risk factor for thromboembolic disease in subclinical hypothyroidism (SH). We measured fibrinolytic activity in patients with SH before and after levothyroxine (LT(4)) treatment and compared it to those of controls. We prospectively included 35 patients with SH and 30 healthy controls. We treated patients with LT(4) until almost 6 months after the euthyroid state has been achieved. We measured fibrinogen, D-dimer, antithrombin III (ATIII), plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) activity, and factor VII. Clinical and anthropometric variables were recorded for both groups. We found increased levels of fibrinogen, PAI-1, and factor VII and decreased levels of ATIII activity in patients compared to control (p < 0.001 and p < 0.05). Decrease of tPA was not significant (p > 0.05). At the end of the LT(4) treatment, significant decreases were determined in PAI-1 and factor VII (p < 0.05). In conclusion, our data suggest an important role of hypofibrinolytic and hypercoagulable state on the development of atherosclerosis in patients with SH and beneficial effects of LT(4 )treatment for decreasing the risk of atherosclerosis.
Zeynep Cantürk; Berrin Cetinarslan; Ilhan Tarkun; Nuh Zafer Cantürk; Meltem Ozden; Can Duman
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  13     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-12     Completed Date:  2004-09-03     Revised Date:  2005-03-10    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  971-7     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Kocaeli University, Medical School, Kocaeli, Turkey.
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MeSH Terms
Blood Pressure
Cardiovascular Diseases / blood,  epidemiology*
Hemostasis / physiology*
Hypothyroidism / blood,  complications*,  drug therapy
Reference Values
Risk Factors
Thyroid Gland / physiology,  physiopathology
Thyrotropin / blood
Thyroxine / blood,  therapeutic use*
Triiodothyronine / blood
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin
Comment In:
Thyroid. 2004 Oct;14(10):870; author reply 871-2   [PMID:  15588388 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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