| Hemostatic studies in racing standardbred horses with exercise-induced pulmonary hemorrhage. Hemostatic parameters at rest and after moderate exercise. | |
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MedLine Citation:
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PMID: 1909208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine whether a defect in hemostasis might be a factor in the etiology of exercise-induced pulmonary hemorrhage (EIPH). Hemostatic parameters were evaluated in 22 EIPH-positive and ten EIPH-negative racing horses while in a rested state. Nineteen EIPH-positive and ten EIPH-negative horses were further evaluated just before and immediately after a 15 min exercise period on a 260 m oval track. When EIPH-positive and EIPH-negative horses were compared at rest, there was no significant difference in any of the coagulation and fibrinolytic parameters studied. There was however, a significant difference in platelet function as assessed by aggregometry. The platelets from affected horses were significantly less responsive than those from nonaffected horses when exposed in vitro to the platelet agonists adenosine diphosphate, collagen and platelet activating factor. Exercise tended to increase the packed cell volume and factor VIII/von Willebrand factor and to decrease platelet aggregation responses to low concentrations of adenosine diphosphate. These effects of exercise however were quantitatively similar in both EIPH-positive and EIPH-negative horses. Reduced platelet function may therefore be a contributing factor in the bleeding characteristic of horses with EIPH. |
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Authors:
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I B Johnstone; L Viel; S Crane; T Whiting |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire Volume: 55 ISSN: 0830-9000 ISO Abbreviation: Can. J. Vet. Res. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-10-09 Completed Date: 1991-10-09 Revised Date: 2010-09-09 |
Medline Journal Info:
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Nlm Unique ID: 8607793 Medline TA: Can J Vet Res Country: CANADA |
Other Details:
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Languages: eng Pagination: 101-6 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Ontario. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Diphosphate
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pharmacology Animals Antithrombin III / analysis Collagen / pharmacology Factor VIII / analysis Fibrin / analysis Fibrin Fibrinogen Degradation Products / analysis Fibrinogen / analysis Hematocrit / veterinary Hemorrhage / blood, etiology, veterinary* Hemostasis* Horse Diseases / blood*, etiology Horses Lung Diseases / blood, etiology, veterinary* Partial Thromboplastin Time / veterinary Physical Exertion* Platelet Activating Factor / pharmacology Platelet Aggregation Platelet Count / veterinary Prothrombin Time / veterinary Thrombin Time / veterinary von Willebrand Factor / analysis |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 0/Platelet Activating Factor; 0/von Willebrand Factor; 58-64-0/Adenosine Diphosphate; 9000-94-6/Antithrombin III; 9001-27-8/Factor VIII; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; 9007-34-5/Collagen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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