Document Detail

Hemostatic role of a folkloric medicinal plant extract in a rat partial nephrectomy model: controlled experimental trial.
MedLine Citation:
PMID:  19303089     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Ankaferd BloodStopper is a mixture of 5 plants used in traditional Turkish medicine as hemostatic agent for external traumatic, postoperative and dental bleeding. We investigated the hemostatic efficacy of Ankaferd BloodStopper for partial nephrectomy. MATERIALS AND METHODS: A total of 24 Wistar rats were divided into 4 groups of 6 each. Group 1 underwent partial nephrectomy with hilar control as the conventional technique. Group 2 underwent the conventional technique with hemostatic agent application. Group 3 underwent hemostatic agent application to the renal parenchyma. In Group 4 partial nephrectomy was performed and the hemostatic agent was used without hilar control. Warm ischemia and partial nephrectomy times, and the number of hemostatic agent applications were recorded. Histopathological evaluations were completed. The Fisher, Kruskal-Wallis and Mann-Whitney U tests were used for statistical analysis. RESULTS: Mean kidney size was 2 x 2.5 x 0.05 cm. Mean partial nephrectomy time was 3.7, 2.7, 1.8 and 3.2 minutes in groups 1 to 4, respectively, which was significantly different between groups 1 and 3 (p = 0.007). Warm ischemia time in group 3 was less than in group 1 (p = 0.011). The number of hemostatic agent applications was higher in groups 3 and 4 compared to those in group 2 (p = 0.003). Glomerular necrosis was detected at a higher rate in group 1 compared to that in groups 3 and 4 (p = 0.015). Calcification formed significantly more in group 1 than in groups 2 to 4 (p <0.05). Erythrocyte aggregation was greater in groups 2 to 4 than in group 1 (p = 0.015). Giant cell reaction, fibrosis, inflammation and microvascular proliferation were not statistically different among the groups (p >0.05). CONCLUSIONS: Ankaferd BloodStopper decreases partial nephrectomy and warm ischemia times, and provides hemostasis. Erythrocyte aggregation confirmed the hemostatic action of the agent, while the absence of glomerular necrosis and calcification may have positive relevance.
Emre Huri; Turgay Akgül; Ali Ayyildiz; Hüseyin Ustün; Cankon Germiyanoğlu
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-03-19
Journal Detail:
Title:  The Journal of urology     Volume:  181     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2349-54     Citation Subset:  AIM; IM    
Second Urology Clinic, Ankara Training and Research Hospital, Ankara, Turkey.
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MeSH Terms
Biopsy, Needle
Blood Loss, Surgical / prevention & control*
Disease Models, Animal
Hemostatic Techniques
Hemostatics / administration & dosage*
Monitoring, Intraoperative
Phytotherapy / methods*
Plant Extracts / pharmacology*
Plants, Medicinal*
Random Allocation
Rats, Wistar
Sensitivity and Specificity
Statistics, Nonparametric
Warm Ischemia
Reg. No./Substance:
0/Hemostatics; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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