Document Detail


Hemostatic parameters in newborn--I. Effect of gestation and rate of intrauterine growth.
MedLine Citation:
PMID:  3705007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study comprises of 208 term, 159 preterm and 18 post-term neonates born to mothers with no history of drug intake or any disease likely to effect coagulation of the newborn. PT, TT and KCCT were relatively prolonged and plasma fibrinogen reduced to varying degree in newborns (as compared to adults). There was further prolongation of TT and reduction in plasma fibrinogen levels amongst preterm newborns as compared to term babies; TT was more prolonged amongst post-term babies also. PT was significantly more prolonged till 30 weeks of gestation, after which a near plateau was formed. KCCT showed significant improvement after 33 weeks and a further trend to normalisation after 38 weeks of gestation. Serum FDP values showed too much of variation for any meaningful statistical analysis but generally FDPs were higher in preterm babies. Intrauterine growth rate had no significant effect on these parameters amongst preterms - similar values for SGA (small for gestational age), AGA (appropriate for gestational age) and LGA (large for gestational age). On the other hand, amongst term babies SGA neonates had significantly prolonged PT and low plasma fibrinogen as compared to AGA; LGA babies also showed more prolongation of TT as compared to AGA.
Authors:
B Dube; R K Dube; V Bhargava; J K Kolindewala; V L Kota; B K Das
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  55     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-05-30     Completed Date:  1986-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Embryonic and Fetal Development
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinogen / metabolism
Gestational Age
Hemostasis*
Humans
Infant, Newborn*
Infant, Postmature
Infant, Premature
Infant, Small for Gestational Age
Partial Thromboplastin Time
Prothrombin Time
Thrombin Time
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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