Document Detail


Hemostatic markers in acute stroke.
MedLine Citation:
PMID:  2718198     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the time course of thrombosis and fibrinolysis after acute stroke, we measured concentrations of fibrinopeptide A (FpA), B-beta 1-42 peptide (B-beta 1-42), B-beta 15-42 peptide (B-beta 15-42), and crosslinked D-dimer (XDP) in 31 patients at varying times following acute ischemic stroke and in 13 neurologically stable patients with chronic strokes. FpA levels were markedly elevated during the first week after stroke and declined slowly during the first month. Mean FpA levels were not significantly elevated in chronic stroke patients. Mean XDP levels were slightly elevated during the first week and increased during the next 2 weeks after stroke. B-beta 1-42 and B-beta 15-42 levels were not elevated at any time following acute stroke. Our data suggest that fibrin formation greatly exceeds endogenous fibrinolysis during the acute phase of ischemic stroke. Endogenous fibrinolysis develops slowly following stroke. Prolonged elevation of FpA concentration suggests that thrombin activity and fibrin formation continue for up to 4 weeks in some patients with ischemic stroke.
Authors:
W M Feinberg; D C Bruck; M E Ring; J J Corrigan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  20     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1989 May 
Date Detail:
Created Date:  1989-06-12     Completed Date:  1989-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  592-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Arizona Health Sciences Center, Tucson 85724.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Aged, 80 and over
Cerebrovascular Disorders / blood*
Female
Fibrin Fibrinogen Degradation Products / analysis*
Fibrinogen / analysis*
Fibrinopeptide A / analysis*
Fibrinopeptide B / analysis*
Humans
Male
Middle Aged
Peptide Fragments / analysis*
Time Factors
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/fibrin fragment D; 0/fibrinogen Bbeta (1-42); 0/fibrinopeptide Bbeta (15-42); 25422-31-5/Fibrinopeptide A; 36204-23-6/Fibrinopeptide B; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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