Document Detail


Hemostatic implications of endothelial cell apoptosis in obstructive sleep apnea.
MedLine Citation:
PMID:  18398629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with obstructive sleep apnea (OSA) are at increased risk of atherothrombosis independent of the Framingham risk factors. Studies on hemostasis factors in OSA are scarce and inconsistent. We sought to understand the variation in atherothrombotic propensity as a function of apoptotic circulating endothelial cells (CECs) in OSA by investigating the relationship between CEC apoptosis and plasma levels of hemostatic factors tissue factor (TF) and von Willebrand Factor (vWF) in apneic subjects. Apoptotic CECs were detected by flow cytometry in 35 male subjects free of cardiovascular diseases (AHI range 8-43) and 12 healthy male controls (AHI range 2-5) before and after 8 weeks of nasal continuous positive airway pressure (nCPAP). Quantitative determination of TF and vWF was performed using an enzyme-linked immunosorbent assay (ELISA) kit. The mean levels of TF (66.78 +/- 41.59 pg/ml) and vWF (189.70 +/- 69.24 IU/dl) were significantly higher in OSA patients compared with those in healthy subjects (42.83 +/- 14.18 pg/ml; and 124.48 +/- 31.43 IU/dl). Apoptotic CECs were elevated in patients with OSA and correlated strongly with TF and vWF levels (p = 0.02 and p < 0.001; respectively). There were no correlations between TF, vWF and apnea hypopnea index, or arousal index. Only the percentage of time spent <90% oxygen saturation was inversely associated with TF (r = 0.38; p = 0.02). Following nCPAP therapy, there was significant decrease in TF levels that correlated with decrease in apoptotic CECs. In patients with OSA, increased prothrombotic factors are strongly determined by apoptotic CECs. Treatment with nCPAP may alleviate the coagulation propensity.
Authors:
Ali A El Solh; Morohunfolu E Akinnusi; Ilya G Berim; A Misha Peter; Linda L Paasch; Kristie R Szarpa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-09
Journal Detail:
Title:  Sleep & breathing = Schlaf & Atmung     Volume:  12     ISSN:  1520-9512     ISO Abbreviation:  Sleep Breath     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-30     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804161     Medline TA:  Sleep Breath     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  331-7     Citation Subset:  IM    
Affiliation:
Western New York Respiratory Research Center, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA. solh@buffalo.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Apoptosis / physiology*
Atherosclerosis / blood*
Continuous Positive Airway Pressure
Endothelium, Vascular / physiopathology*
Enzyme-Linked Immunosorbent Assay
Hemostasis / physiology*
Humans
Male
Oxygen / blood
Polysomnography
Reference Values
Risk Factors
Sleep Apnea, Obstructive / blood*,  therapy
Thrombophilia / blood,  therapy
Thromboplastin / metabolism
Thrombosis / blood*
von Willebrand Factor / metabolism
Chemical
Reg. No./Substance:
0/von Willebrand Factor; 7782-44-7/Oxygen; 9035-58-9/Thromboplastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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