| Hemostatic and hemodynamic effects of vasopressin analogue DDAVP in patients with cirrhosis. | |
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MedLine Citation:
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PMID: 9339235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Desmopressin (DDAVP), a synthetic analogue of vasopressin, has been shown to improve the bleeding time in patients with cirrhosis. The duration of this effect and the hemodynamic changes associated with DDAVP have not been studied so far. To evaluate these issues, 14 cirrhotics with portal hypertension were studied in basal conditions and after DDAVP (0.3 uk/kg). In 8 patients, hemostatic tests were done at basal conditions and 1, 3, 6 and 24 hs after drug administration. In the remaining 6 patients, mean arterial pressure, cardiac output, portal and femoral blood flows were evaluated. Hemodynamic parameters were measured by Doppler ultrasound. DDVP caused a marked decrease in bleeding time at 1, 3, 6 and 24 hs (14 +/- 9 vs 8 +/- 3, 7 +/- 4, 6 +/- 4 and 8 +/- 4 min, respectively); the decrease was maximal and statistically significant at 6 hs (55 +/- 15%, p < 0.02) after DDAVP infusion. Bleeding time reduction was observed in every patient studied. In the hemodynamic study, DDAVP caused a mild but significant decrease in mean arterial pressure (12 +/- 8%, p < 0.05); no significant changes were observed in the rest of hemodynamic parameters studied. These findings show that DDAVP can be used to shorten the bleeding time for a period of at least 24 hs in patients with cirrhosis, without deleterious hemodynamic effects. This beneficial effect may be of potential relevance in the medical management of patients with chronic liver diseases. |
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Authors:
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P López; J C Otaso; D Alvarez; S Rojter; A Podestá; L Albornoz; R Terg; G Romero; R Mastai |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Acta gastroenterologica Latinoamericana Volume: 27 ISSN: 0300-9033 ISO Abbreviation: Acta Gastroenterol. Latinoam. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-12-02 Completed Date: 1997-12-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0261505 Medline TA: Acta Gastroenterol Latinoam Country: ARGENTINA |
Other Details:
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Languages: eng Pagination: 59-62 Citation Subset: IM |
Affiliation:
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Sección de Hígado, Hospital Italiano, Buenos Aires, Argentina. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bleeding Time Deamino Arginine Vasopressin / pharmacology*, therapeutic use Female Hemodynamics / drug effects* Hemostasis / drug effects* Humans Hypertension, Portal / drug therapy* Liver Cirrhosis / drug therapy* Male Middle Aged Renal Agents / pharmacology*, therapeutic use Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Renal Agents; 16679-58-6/Deamino Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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