| Hemostatic function in cancer patients. | |
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MedLine Citation:
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PMID: 7397648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed coagulation profiles including a complete blood count (CBC), prothrombin time (PT), activated partial thromboplastin time (aPTT), and quantitation of fibrinogen, antithrombin III (AT III), plasminogen, and fibrin/fibrinogen degradation products (FDP) on 73 cancer patients. All had solid tumors with clinically documented metastases. Eleven patients had strong clinical and laboratory evidence of disseminated intravascular coagulation (DIC). Fifty-five of the remaining 62 patients had no clinical evidence of serious hemorrhage or thrombosis at the time of testing. Thirty-one (50%) non-DIC patients had no abnormal clotting tests. Our data indicate that a majority of cancer patients, with or without hepatic involvement, are able to maintain normal or near normal hemostatic function in vitro until advanced stage of disease. Deviation from normal for PT, aPTT, or TT, depressed AT III activity, or increased FDP signal the presence of complicating pathophysiologic events such as DIC or cirrhosis. Diminution of fibrinogen level or AT III activity and elevation of FDP are more sensitive indicators of DIC than prolongation of PT, aPTT, or TT. |
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Authors:
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M S Kies; J J Posch; J P Giolma; R N Rubin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 46 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1980-10-24 Completed Date: 1980-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 831-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antithrombin III / analysis Blood Coagulation Tests Disseminated Intravascular Coagulation / etiology Female Fibrin Fibrinogen Degradation Products / analysis Fibrinogen / analysis Hemostasis* Humans Liver Cirrhosis / etiology Male Middle Aged Neoplasm Metastasis Neoplasms / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Fibrinogen Degradation Products; 9000-94-6/Antithrombin III; 9001-32-5/Fibrinogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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