| Hemostatic function and carotid artery disease. | |
| | |
MedLine Citation:
|
PMID: 15156124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: Since conventional risk factors predict less than one half of future cardiovascular events, other factors that contribute to atherogenesis need to be evaluated. The aim of this study was to investigate whether clotting factors are associated with carotid artery disease. Furthermore, we tried to determine whether clotting factors could be used to predict the risk of cerebrovascular events in patients with internal carotid artery stenosis. METHODS: Twenty-six patients with high-grade (>70%) internal carotid artery stenosis and 43 age-matched controls were evaluated for atherogenic risk factors and hemostatic function. Laboratory tests included plasma assays of fibrinogen, tissue plasminogen activator (TPA), D-dimer, plasminogen activator inhibitor 1 (PAI-1), plasminogen and factor VII:c. Nineteen (72%) patients had history of stroke or transient ischemic attack, while the remaining 7 (28%) were asymptomatic. Statistical analysis was performed using multiple linear regression analysis. RESULTS: Carotid artery stenosis was associated with high levels of TPA (p<0.001), D-dimer (p=0.019) and PAI-1 (p<0.001). No statistically significant correlation was found between the presence of carotid artery disease and the levels of fibrinogen (p=0.28), plasminogen (p=0.96) or factor VII:c (p=0.19). As regards the clinical manifestations, none of the studied clotting factors was correlated with the history of cerebrovascular events in the patients with carotid stenosis. CONCLUSION: The results of this study show that the hemostatic system may play a role in the development of carotid artery atherosclerotic disease, while it does not seem to affect the development of symptoms in patients with carotid stenosis. |
| | |
Authors:
|
C Liapis; J Kakisis; V Papavassiliou; C Tsoukala; T Makris; E Kaperonis; A Psifis; A Karafoulidou; A Kostakis |
Related Documents
:
|
11107084 - Initial evaluation of carotid angioplasty and stenting with three different cerebral pr... 7738594 - Differentiation of embolic and thrombotic middle cerebral artery occlusion using ultras... 19418114 - Stroke in an adult with hiv infection due to carotid artery stenosis successfully treat... 7619184 - A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat ... 3105174 - Isolated amyloidosis of the atrioventricular valves. a study of one case, curiously ass... 23645544 - Resolution of trigeminal neuralgia by coil embolization of a persistent primitive trige... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International angiology : a journal of the International Union of Angiology Volume: 23 ISSN: 0392-9590 ISO Abbreviation: Int Angiol Publication Date: 2004 Mar |
Date Detail:
|
Created Date: 2004-05-24 Completed Date: 2005-01-05 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8402693 Medline TA: Int Angiol Country: Italy |
Other Details:
|
Languages: eng Pagination: 14-7 Citation Subset: IM |
Affiliation:
|
Second Department of Propedeutic Surgery, Athens University Medical School, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Carotid Artery Diseases / blood*, physiopathology* Female Hemostasis* Humans Male Middle Aged Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A case of chronic acalculous cholecystitis diagnosed by delayed contrast emptying in gallbladder
Next Document: Increased soluble E-selectin levels in type 2 diabetic patients with peripheral arterial disease.