Document Detail


Hemostatic and fibrinolytic effects of systemic prostaglandin E1 therapy in patients with peripheral arterial disease.
MedLine Citation:
PMID:  14524034     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The study was designed to evaluate if there is any evidence of a hyperfibrinolytic bleeding-risk under systemic treatment with prostaglandin E1 (PGE1) of patients with peripheral arterial disease (PAD).
PATIENTS AND METHODS: The in vivo effect of PGE1 on the fibrinolytic and hemostatic process was tested on 15 patients before and after treatment with Alprostadil for 21 days using D-dimers (DD), fibrinogen, prothrombin time (PT), partial thromboplastin time (PTT), antithrombin (AT), ProC-Global, plasminogen, plasminogen activator inhibitor activity (PAI), alpha 2-antiplasmin, coagulation factor XII, basal and activated fibrinolytic capacity (fib. cap.).
RESULTS: There was no significant difference in DD, fibrinogen, PT, PTT, AT, ProC-Global, plasminogen, PAI, alpha 2-antiplasmin, coagulation factor XII, basal and activated fibrinolytic capacity observed after the treatment.
CONCLUSION: Summarizing this study there is no hyperfibrinolytic bleeding-risk after the systemic therapy with Alprostadil to be expected.
Authors:
M Kuss; H Heidrich; E Koettgen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  VASA. Zeitschrift für Gefässkrankheiten     Volume:  32     ISSN:  0301-1526     ISO Abbreviation:  VASA     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2004-01-15     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  0317051     Medline TA:  Vasa     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
Affiliation:
Institut für Laboratoriumsmedizin und Pathobiochemie, Medizinischen Fakultät Charité, Humboldt-Universität zu Berlin, Germany. marcella.kuss@web.de
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alprostadil / administration & dosage,  adverse effects*
Arterial Occlusive Diseases / blood,  drug therapy*
Blood Coagulation Factors / metabolism
Blood Coagulation Tests
Female
Fibrinolysis / drug effects*
Fibrinolytic Agents / adverse effects*
Hemorrhage / blood,  chemically induced*
Hemostasis / drug effects*
Humans
Infusions, Intravenous
Male
Middle Aged
Risk Assessment
Chemical
Reg. No./Substance:
0/Blood Coagulation Factors; 0/Fibrinolytic Agents; 745-65-3/Alprostadil

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