| Hemostatic action of OC-108, a novel agent for hemorrhoids, is associated with regional blood flow arrest induced by acute inflammation. | |
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MedLine Citation:
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PMID: 17072100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinically, hemorrhoidal bleeding and prolapse disappeared immediately after injection of the sclerosing agent OC-108 into submucosa of hemorrhoids. The aim of this study was to elucidate the mechanism of action responsible for the immediate hemostatic effect of OC-108 using anesthetized rats. Subcutaneous injection of OC-108 in rats decreased blood flow at the injection site within 5 min. Aluminum potassium sulfate, one of the main ingredients of OC-108, reduced the skin blood flow. However, tannic acid, another main ingredient, did not. By perfusion of OC-108 on the mesenteric surface, microcirculatory blood flow was arrested without remarkable change in blood vessel diameter, accompanied by increased vascular permeability and venous hematocrit. These results indicate that OC-108 induces regional blood flow arrest with rapid onset, this effect being attributed to the action of aluminum potassium sulfate, and that hemoconcentration due to increased vascular permeability (plasma extravasation), an acute inflammatory reaction, is involved in the mechanisms of the immediate hemostatic action of OC-108. |
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Authors:
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Takashi Ono; Haruto Nakagawa; Atsushi Fukunari; Toshio Hashimoto; Hirotsugu Komatsu |
Publication Detail:
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Type: Journal Article Date: 2006-10-28 |
Journal Detail:
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Title: Journal of pharmacological sciences Volume: 102 ISSN: 1347-8613 ISO Abbreviation: J. Pharmacol. Sci. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-22 Completed Date: 2007-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167001 Medline TA: J Pharmacol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 314-20 Citation Subset: IM |
Affiliation:
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Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Ono.Takashi@md.m-pharma.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Alum Compounds / pharmacology* Anesthesia Animals Blood Cell Count Capillary Permeability / drug effects Hematocrit Hemorrhoids / drug therapy* Hemostatics* Inflammation / physiopathology* Male Mesenteric Arteries / physiology Mesenteric Veins / physiology Rats Rats, Wistar Regional Blood Flow / drug effects Splanchnic Circulation / drug effects Tannins / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Alum Compounds; 0/Hemostatics; 0/OC-108; 0/Tannins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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