| Hemostatic factors and subclinical brain infarction in a community-based sample: the ARIC study. | |
| | |
MedLine Citation:
|
PMID: 19844099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Previous data are conflicting as to whether imbalance between hemostatic factors is associated with clinical strokes. We evaluated the association between hemostatic factor levels and subclinical lacunar infarcts in a nested sample from a subset of the Atherosclerosis Risk in Communities (ARIC) cohort. METHODS: 196 cases without clinical strokes had lacunar infarcts by MRI, and 214 controls without radiographic infarcts were frequency-matched by age group and sex. Logistic regression models were fitted to assess the association between levels of hemostatic markers and case status. RESULTS: In age-, race- and sex-adjusted models, von Willebrand factor (vWF) and D-dimer were positively associated with case status, with odds ratios for the highest vs. lowest tertile of 2.0 (95% CI 1.2-3.6) for vWF and 1.76 (95% CI 1.02-3.0) for D-dimer. Plasminogen had nonsignificant inverse associations with presence of silent lacunar infarcts. CONCLUSIONS: vWF and D-dimer were positively associated, and plasminogen was nonsignificantly inversely associated with subclinical radiographic infarct. Further studies on the role of these hemostatic factors in the development of silent lacunar infarcts may help elucidate the mechanisms behind this injury and may even point to potential targets for future intervention. |
| | |
Authors:
|
R F Gottesman; C Cummiskey; L Chambless; K K Wu; N Aleksic; A R Folsom; A R Sharrett |
Related Documents
:
|
20406769 - Atrial fibrillation management strategies and early mortality after myocardial infarcti... 9270949 - Prevalence, determinants, and misclassification of myocardial infarction in the elderly. 8313549 - Exercise technetium-99m sestamibi tomography for cardiac risk stratification of patient... 16263889 - Meta-analysis: secondary prevention programs for patients with coronary artery disease. 12390949 - Comparative survival of dialysis patients in the united states after coronary angioplas... 9744969 - Trends in the incidence of myocardial infarction and in mortality due to coronary heart... 4071169 - Community-acquired febrile illness in patients with prosthetic heart valves. 6215869 - Coincidence of cerebrovascular accident and silent myocardial infarction. 7079319 - Heart rate mechanisms in instrumental conditioning reinforced by petting in dogs. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-10-16 |
Journal Detail:
|
Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 28 ISSN: 1421-9786 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-11-26 Completed Date: 2010-02-24 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 589-94 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2009 S. Karger AG, Basel. |
Affiliation:
|
Department of Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD 21287, USA. rgottesm@jhmi.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Atherosclerosis
/
epidemiology Biological Markers / blood Brain Infarction / blood*, epidemiology*, pathology Case-Control Studies Cross-Sectional Studies Female Fibrin Fibrinogen Degradation Products / metabolism* Humans Logistic Models Magnetic Resonance Imaging Male Middle Aged Plasminogen / metabolism* Predictive Value of Tests Retrospective Studies Risk Factors United States / epidemiology von Willebrand Factor / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
|
N01 HC055015/HC/NHLBI NIH HHS; N01 HC055016/HC/NHLBI NIH HHS; N01 HC055018/HC/NHLBI NIH HHS; N01 HC055019/HC/NHLBI NIH HHS; N01 HC055020/HC/NHLBI NIH HHS; N01 HC055021/HC/NHLBI NIH HHS; N01 HC055022/HC/NHLBI NIH HHS; N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55020/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 0/von Willebrand Factor; 9001-91-6/Plasminogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Indices of Kidney Dysfunction and Discharge Outcomes in Hospitalized Stroke Patients without Known R...
Next Document: Safety of Eptifibatide for Subcortical Stroke Progression.