Document Detail


Hemostatic factors and subclinical brain infarction in a community-based sample: the ARIC study.
MedLine Citation:
PMID:  19844099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous data are conflicting as to whether imbalance between hemostatic factors is associated with clinical strokes. We evaluated the association between hemostatic factor levels and subclinical lacunar infarcts in a nested sample from a subset of the Atherosclerosis Risk in Communities (ARIC) cohort.
METHODS: 196 cases without clinical strokes had lacunar infarcts by MRI, and 214 controls without radiographic infarcts were frequency-matched by age group and sex. Logistic regression models were fitted to assess the association between levels of hemostatic markers and case status.
RESULTS: In age-, race- and sex-adjusted models, von Willebrand factor (vWF) and D-dimer were positively associated with case status, with odds ratios for the highest vs. lowest tertile of 2.0 (95% CI 1.2-3.6) for vWF and 1.76 (95% CI 1.02-3.0) for D-dimer. Plasminogen had nonsignificant inverse associations with presence of silent lacunar infarcts.
CONCLUSIONS: vWF and D-dimer were positively associated, and plasminogen was nonsignificantly inversely associated with subclinical radiographic infarct. Further studies on the role of these hemostatic factors in the development of silent lacunar infarcts may help elucidate the mechanisms behind this injury and may even point to potential targets for future intervention.
Authors:
R F Gottesman; C Cummiskey; L Chambless; K K Wu; N Aleksic; A R Folsom; A R Sharrett
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-10-16
Journal Detail:
Title:  Cerebrovascular diseases (Basel, Switzerland)     Volume:  28     ISSN:  1421-9786     ISO Abbreviation:  Cerebrovasc. Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-26     Completed Date:  2010-02-24     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  9100851     Medline TA:  Cerebrovasc Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / epidemiology
Biological Markers / blood
Brain Infarction / blood*,  epidemiology*,  pathology
Case-Control Studies
Cross-Sectional Studies
Female
Fibrin Fibrinogen Degradation Products / metabolism*
Humans
Logistic Models
Magnetic Resonance Imaging
Male
Middle Aged
Plasminogen / metabolism*
Predictive Value of Tests
Retrospective Studies
Risk Factors
United States / epidemiology
von Willebrand Factor / metabolism*
Grant Support
ID/Acronym/Agency:
N01 HC055015/HC/NHLBI NIH HHS; N01 HC055016/HC/NHLBI NIH HHS; N01 HC055018/HC/NHLBI NIH HHS; N01 HC055019/HC/NHLBI NIH HHS; N01 HC055020/HC/NHLBI NIH HHS; N01 HC055021/HC/NHLBI NIH HHS; N01 HC055022/HC/NHLBI NIH HHS; N01-HC-55015/HC/NHLBI NIH HHS; N01-HC-55016/HC/NHLBI NIH HHS; N01-HC-55018/HC/NHLBI NIH HHS; N01-HC-55019/HC/NHLBI NIH HHS; N01-HC-55020/HC/NHLBI NIH HHS; N01-HC-55021/HC/NHLBI NIH HHS; N01-HC-55022/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 0/von Willebrand Factor; 9001-91-6/Plasminogen
Comments/Corrections

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