Document Detail

Hemostasis in newborns of smoking and nonsmoking mothers.
MedLine Citation:
PMID:  9077625     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine the effect of smoking during pregnancy on neonatal hemostasis. STUDY DESIGN: Venous blood samples of 26 newborns of smoking and 25 newborns of nonsmoking mothers were obtained from the clamped umbilical cord immediately after birth. Prothrombin fragment 1+2, thrombin-antithrombin III complex, plasmin-alpha2-antiplasmin complex, and D-dimer levels were determined to assess activation of coagulation and fibrinolysis. Cotinine was measured in all neonates to objectify cigarette smoke exposure. The Mann-Whitney U test was used to compare the differences between the values of the parameters of coagulation and fibrinolysis in the two groups at the p < 0.05 level. RESULTS: The median values of prothrombin fragment 1+2 and thrombin-antithrombin III complex in newborns exposed to tobacco smoke in utero did not differ from values of newborns who were not exposed. Nor were the markers of fibrinolysis, plasmin-alpha2-antiplasmin complex and D-dimer levels, influenced by tobacco smoke exposure. CONCLUSION: The balance between the components of coagulation and fibrinolytic pathways in neonates is not disturbed by maternal smoking.
P E Mercelina-Roumans; J M Ubachs; J W van Wersch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  176     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-10     Completed Date:  1997-04-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  662-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, De Wever Hospital, Heerlen, The Netherlands.
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MeSH Terms
Antifibrinolytic Agents*
Antithrombin III / analysis
Blood Coagulation* / drug effects,  physiology
Cotinine / blood
Fibrin Fibrinogen Degradation Products / analysis
Fibrinolysin / analysis
Fibrinolysis* / drug effects,  physiology
Hemostasis / drug effects*,  physiology
Infant, Newborn / blood*
Peptide Fragments / analysis
Peptide Hydrolases / analysis
Prothrombin / analysis
Reference Values
alpha-2-Antiplasmin / analysis
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Fibrin Fibrinogen Degradation Products; 0/Peptide Fragments; 0/alpha-2-Antiplasmin; 0/antithrombin III-protease complex; 0/fibrin fragment D; 0/plasmin-plasmin inhibitor complex; 0/prothrombin fragment 1.2; 486-56-6/Cotinine; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; EC 3.4.-/Peptide Hydrolases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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