Document Detail


Hemostasis Parameters Disturbances in Healthy Individuals with Prehypertension.
MedLine Citation:
PMID:  22712567     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Prehypertension (PH) seems to be related to increased cardiovascular risk in healthy normotensive subjects, while essential hypertension is associated with hemostasis balance disturbances. The aim of our study was to examine the impact of PH on hemostasis parameters in healthy individuals with PH and to compare the findings with those of healthy normotensives with normal blood pressure (NBP) levels. This study was performed in 204 (96 M, 108 F) subjects who attended our hypertension clinic. Seventy-eight (36 M, 42 F) subjects with PH, mean age 52 ± 5 years, and body mass index (BMI) 23 ± 1.5 kg/m(2) made up group A, and 126 (60 M, 66 F) subjects with NBP, mean age 53 ± 6 years, and BMI 23.2 ± 1.4 kg/m(2) without any history of cardiovascular disease or diabetes mellitus made up group B. Systolic blood pressure and diastolic blood pressure were measured in three sequential visits, which were performed by the same trained nurse. Serum lipid levels, fibrinogen (F), thrombomodulin (TM), and plasminogen activator inhibitor-1 antigen, and tissue plasminogen activator antigen were determined in the whole population. Plasminogen activator inhibitor-1 antigen and tissue plasminogen activator antigen levels were significantly higher in the PH group as compared with normotensives, while in PH subjects, significantly higher plasma levels of F and TM were found compared with normotensive group. The two groups were matched for age, sex, BMI, and serum lipid levels. Our findings indicate that PH is associated with hemostasis disturbances predisposing to hypercoagulability and impaired fibrinolysis. This observation may be of prognostic value for future cardiovascular events in this group and needs further investigation.
Authors:
Dimitris Papadopoulos; Iordanis Mourouzis; Athanasia Kotrotsou; Urania Papazachou; Elias Sanidas; Kostas Tsioufis; Thomas Makris
Related Documents :
22415387 - Noninvasive continuous arterial blood pressure monitoring with nexfin.
22723577 - Intensive blood pressure treatment does not improve cardiovascular outcomes in centrall...
1380607 - Cardiovascular and adenylate cyclase stimulant properties of nkh477, a novel water-solu...
7921867 - The direct cardiac effects of ketamine studied on the intact isolated rabbit heart.
2353347 - Blood pressure, obesity and urine cation excretion in two populations of the cook islands.
22258447 - Snake modulates constriction in response to prey's heartbeat.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  -     ISSN:  1525-6006     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
ESH Excellent Center of Hypertension, Laiko University Hospital , Athens , Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lack of sensitivity of the 1 ?g low-dose ACTH stimulation test in a paediatric population with subop...
Next Document:  Urologists and oncologists: adapting to a new treatment paradigm in castration-resistant prostate ca...