Document Detail

Hemorrhagic peritoneal carcinomatosis treated with a weekly schedule of carboplatin and paclitaxel. A case report.
MedLine Citation:
PMID:  12908796     Owner:  NLM     Status:  MEDLINE    
Ovarian carcinomas are chemosensitive tumors. Chemotherapy plays a pivotal role also in advanced disease, and the response to chemotherapy appears to be predictive of prolonged survival. Only performance status seems to limit therapy administration and affect patient survival. Here we report on a 66-year-old patient with a clinical status heavily compromised by peritoneal carcinomatosis associated with bloody effusion, which required increasingly frequent paracentesis and transfusions. The clinical conditions worsened under carboplatin monochemotherapy. A further attempt with carboplatin and paclitaxel in a weekly schedule resulted in a clinical response in terms of reduced need for paracentesis and blood support and improved performance status. This case confirms that treatment is the only chance to improve clinical status even in patients with very advanced ovarian cancer and an extensive tumor load. In our opinion, the modified schedule adopted in the case presented here may be worthwhile for future phase II studies in a selected patient population.
Liliana Montella; Antonella Vardanega; Bortolo Perin; Carmelo Zappalà; Giorgio Bonciarelli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Tumori     Volume:  89     ISSN:  0300-8916     ISO Abbreviation:  Tumori     Publication Date:    2003 May-Jun
Date Detail:
Created Date:  2003-08-11     Completed Date:  2003-09-03     Revised Date:  2008-12-12    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  336-9     Citation Subset:  IM    
Dipartimento Medico, Unità Operativa di Oncologia Medica, ULSS 17 Veneto, Montagnana (Padua), Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Carboplatin / administration & dosage
Carcinoma / drug therapy*,  pathology
Hemorrhage / drug therapy*,  pathology
Ovarian Neoplasms / drug therapy*,  pathology
Paclitaxel / administration & dosage
Peritoneal Neoplasms / drug therapy*,  pathology
Treatment Outcome
Reg. No./Substance:
33069-62-4/Paclitaxel; 41575-94-4/Carboplatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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