Document Detail

Hemorrhagic fever with renal syndrome in Korea.
MedLine Citation:
PMID:  2568676     Owner:  NLM     Status:  MEDLINE    
Several clinical variants of hemorrhagic fever with renal syndrome (HFRS) are caused by Hantaan and related viruses. Since 1951, 500-900 patients with HFRS have been hospitalized annually in Korea. Although HFRS is associated primarily with rural areas, it is now being recognized as an urban problem and a particular hazard to laboratory staff using rodents for research. Recently, epidemic outbreaks of leptospirosis and scrub typhus have occurred during the HFRS season, leading to confusion in diagnosis. Serologic diagnosis of HFRS is based on the demonstration of IgM antibodies to Hantaviruses by the indirect fluorescent antibody technique or enzyme-linked immunosorbent assay. The specific Hantavirus causing infection can be identified on the basis of titers of plaque-reduction neutralizing antibody. Results of studies with monoclonal antibodies suggest that viral subtypes exist for each Hantaviral serotype presently recognized. While infection with Hantaviruses is known to be a problem of worldwide dimensions, present evidence indicates that it occurs over a wider area than previously recognized. Vertical transmission of Hantaan virus in a pregnant woman has been documented.
H W Lee
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  11 Suppl 4     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1989 May-Jun
Date Detail:
Created Date:  1989-08-16     Completed Date:  1989-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S864-76     Citation Subset:  IM    
World Health Organization Collaborating Centre for Virus Reference and Research, Institute for Viral Diseases, Korea University, Seoul.
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MeSH Terms
Disease Outbreaks*
Disease Reservoirs
Hemorrhagic Fever with Renal Syndrome / diagnosis,  epidemiology*,  transmission

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