Document Detail

Hemorrhagic endovasculitis of the placenta: an indepth morphologic appraisal with initial clinical and epidemiologic observations.
MedLine Citation:
PMID:  6379579     Owner:  NLM     Status:  MEDLINE    
A vasodestructive process has been identified within the placenta, which focuses on the entire placental vascular tree. Its presence is correlated with significant fetal mortality; liveborn infants are growth retarded and frequently in distress. Characteristic morphologic features have been identified in chorionic vessels of all sizes and these explicit pathologic changes are repetitive from case to case. Associated events suggest that hemorrhagic endovasculitis of the placenta is a clinicopathologic entity having maximal impact on pregnancies of affected patients. A number of accompanying pathologic and clinical features would suggest an infectious association or cause. There are several known categories of disease which manifest similarity to this placental alteration. These include microangiopathic hemolytic anemia, several postinfectious states, several known types of vasculitis, and AIDS. Long-term studies to gain further insight into this pathologic event are currently underway at the Michigan Placental Tissue Registry. These studies include: an epidemiologic field investigation with followup on growth and development of liveborn infants; data collection and analysis with respect to recurrence, geographic distribution, and the clinical course of affected pregnancies. An indepth pathologic analysis is ongoing including ultrastructural and immunopathologic studies on affected and control placentas. Appropriate microbiologic and serologic studies are planned with reference to the infectious aspects of this entity we have described. It is hoped that increasing awareness of this pathologic process within the placenta, particularly by pathologists, will contribute to our understanding of events which are deleterious to intrauterine growth and survival.
C H Sander; N G Stevens
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Pathology annual     Volume:  19 Pt 1     ISSN:  0079-0184     ISO Abbreviation:  Pathol Annu     Publication Date:  1984  
Date Detail:
Created Date:  1984-09-07     Completed Date:  1984-09-07     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0050610     Medline TA:  Pathol Annu     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  37-79     Citation Subset:  IM; X    
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MeSH Terms
Acquired Immunodeficiency Syndrome / pathology
Anemia, Hemolytic / pathology
Capillaries / pathology,  ultrastructure
Chorionic Villi / pathology
Erythroblastosis, Fetal / pathology
Fetal Death / etiology
Microscopy, Electron
Placenta Diseases / complications,  etiology,  pathology*
Purpura, Schoenlein-Henoch / complications,  etiology,  pathology*
Thrombosis / pathology
Trophoblasts / pathology
Umbilical Cord / pathology
Virus Diseases / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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