Document Detail

Hemorrhagic endovasculitis-like lesion induced in placental organ culture.
MedLine Citation:
PMID:  3346008     Owner:  NLM     Status:  MEDLINE    
In organ culture, human chorionic villi develop vascular changes that resemble so-called hemorrhagic endovasculitis. The latter is a morphologic finding more prevalent in placentas of stillborn infants but seen also in those of liveborn infants, in whom the lesion is localized rather than generalized. We compared the histologic vascular changes in short-term organ cultures of 15 placentas (10 term, 5 preterm) with the naturally occurring vascular lesion in 6 placentas (2 liveborn, 4 stillborn). All organ cultures of placentas from liveborn infants developed hemorrhagic endovasculitis-like lesions in the fetal stem arteries; these lesions were present as early as 1 day and persisted for 7 days in culture. A mechanism common to both the in vivo and in vitro systems depending on hypoxia and vascular smooth muscle contraction may explain both the naturally occurring and tissue culture-induced lesions.
M M Silver; H Yeger; L D Lines
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human pathology     Volume:  19     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-19     Completed Date:  1988-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-6     Citation Subset:  IM    
Department of Pathology, Hospital for Sick Children, Toronto General Hospital, Ontario, Canada.
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MeSH Terms
Chorionic Villi / pathology
Fetal Death / pathology
Microscopy, Electron
Organ Culture Techniques
Placenta / pathology*
Purpura, Schoenlein-Henoch / pathology*

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