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Hemorrhagic Vestibular Schwannoma: Review of the Literature.
MedLine Citation:
PMID:  23454397     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Clinically significant intratumoral hemorrhage has historically been reported in only a small fraction of vestibular schwannomas (VS). Cases of hemorrhagic VS are more likely to present with neurologic deficits and have worse outcomes than non-hemorrhagic VS. The purpose of our study was to analyze characteristics that may predispose VS to hemorrhage and that may prove helpful in the management and treatment of VS. METHODS: A literature search was conducted using National Library of Medicine and National Institutes of Health databases to identify articles pertaining to intratumoral hemorrhage in VS. Thirty-nine cases, described in 18 published articles, were selected and reviewed. RESULTS: Average patient age and tumor size in hemorrhagic cases did not differ significantly from non-hemorrhagic cases of VS. Facial nerve dysfunction at presentation occurred with greater frequency in cases of hemorrhagic VS (33.3%) than in non-hemorrhagic VS (6.0%). Death occurred much more frequently in cases of hemorrhagic VS (10.0%) than in non-hemorrhagic VS (0.2%). Abnormality of tumor-associated vasculature was noted histologically in many cases, and a large number of the cases reported prior treatment by stereotactic radiosurgery. CONCLUSIONS: Understanding the origins and clinical implications of intratumoral hemorrhage in VS could potentially assist in the process of clinical decision-making and patient counseling.
Authors:
Yashar S Niknafs; Anthony C Wang; Khoi D Than; Arnold B Etame; B Gregory Thompson; Stephen E Sullivan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-27
Journal Detail:
Title:  World neurosurgery     Volume:  -     ISSN:  1878-8750     ISO Abbreviation:  World Neurosurg     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-3-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528275     Medline TA:  World Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan, USA.
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