Document Detail

Hemorrhage, phenobarbital, and fluctuating cerebral blood flow velocity in the neonate.
MedLine Citation:
PMID:  3050864     Owner:  NLM     Status:  MEDLINE    
Fifty-one sequential intubated babies with birth weights of less than 1,751 were evaluated by serial Doppler ultrasound during the first three days of life. These babies were part of a phenobarbital prophylaxis trial cohort study. Subependymal-intraventricular hemorrhage developed in 17 of the babies. Infants with subependymal-intraventricular hemorrhage, whether or not they received pancuronium or phenobarbital, had coefficients of variation comparable to those of babies without hemorrhage. Coefficient of variation values of the right were comparable to values obtained from the left anterior cerebral artery complex and did not appear to be consistently altered by the presence of subependymal-intraventricular hemorrhage. Coefficient of variation values appeared to be consistently greatest on day 1 and lowest on day 2. In addition, the values overall increased as the number of waves used to determine the coefficient of variation enlarged from five to 20. This phenomena, however, was not seen among pancuronium recipients and suggests that movement artifact may be a determinant of coefficient of variation values. We conclude that, when the best 20 waves are chosen to evaluate the coefficient of variation, no association exists between coefficient of variation values and development of subependymal-intraventricular hemorrhage or administration of phenobarbital.
K C Kuban; H Skouteli; A Cherer; E Brown; A Leviton; M Pagano; E Allred; K F Sullivan
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  82     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-03     Completed Date:  1988-11-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  548-53     Citation Subset:  AIM; IM    
Department of Neurology, Harvard Medical School, Boston.
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MeSH Terms
Blood Flow Velocity / drug effects
Cerebral Hemorrhage / physiopathology,  prevention & control*
Cerebrovascular Circulation
Clinical Trials as Topic
Cohort Studies
Infant, Newborn
Pancuronium / therapeutic use
Phenobarbital / therapeutic use*
Grant Support
Reg. No./Substance:
0/Pancuronium; 50-06-6/Phenobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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