Document Detail


Hemorheological disturbances in cerebrovascular diseases.
MedLine Citation:
PMID:  18503150     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the study was to evaluate the possible relationship of the hemorheological disturbances with the clinical symptoms and some risk factors (RF) for cerebrovascular diseases (CVD). The study included 68 patients with CVD, 29 with transient ischemic attacks (TIA) and 39 with chronic unilateral cerebral infarctions (UCI) and 47 healthy control subjects. A questionnaire for RF for CVD was filled. Hemorheological variables: leucocytes, hemoglobin, hematocrit, fibrinogen (Fib), plasma (PV) and whole blood viscosity (WBV) at different shear rates by Couette rotational viscometer Contraves Low Shear 30 were investigated and the hemorheological indices of erythrocyte aggregation (IEA), erythrocyte deformability (IED) and of oxygen transport to tissues (TO(2)) were calculated. The arterial hypertension was the most frequent RF in the examined patients'. The hemorheological investigation showed significant increase of Fib in the patients with TIA and of PV and WBV in both patients' groups. The comparative study of the hemorheological variables with the RF for CVD showed predominating significant correlations with blood pressure (systolic, diastolic and mean) values, with age, cholesterol, physical activity and the body mass index. Our study confirms the possibility the hemorheological variables to be accepted as RF for development of stroke and for its recurrences.
Authors:
I Velcheva; N Antonova; E Titianova; P Damianov; N Dimitrov; V Dimitrova
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  39     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Affiliation:
Department of Neurology, Medical University, Sofia, Bulgaria. ivelcheva@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cerebrovascular Disorders / complications*
Erythrocyte Aggregation
Erythrocyte Deformability
Female
Hematologic Diseases / complications,  diagnosis
Hemorheology / methods*
Humans
Hypertension / complications,  diagnosis
Ischemic Attack, Transient / complications,  diagnosis
Male
Middle Aged
Oxygen / metabolism
Stroke / complications,  diagnosis
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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