Document Detail


Hemorheological correlates of fitness and unfitness in athletes: moving beyond the apparent "paradox of hematocrit"?
MedLine Citation:
PMID:  12775898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Negative correlations between blood viscosity parameters and fitness have been reported, but their physiological meaning remains incompletely understood. Since rheo-active treatments are used in athletes doping, we aimed at clarifying the relationships between hematocrit (Hct), viscosity and performance by comparing aerobic capacity, overtraining questionnaire, and hemorheological parameters. SUBJECTS AND METHODS: 29 sportsmen (24.71+/-1.05 yr; 74.90+/-1.44 kg; 178.5+/-1.05 cm) underwent a standardised exercise test. Physical working capacity (W170), maximal power output (Wmax) and maximal oxygen consumption (VO2max ) were calculated. Viscometric measurements were done with a MT 90 Medicatest viscosimeter. Hct was measured with microcentrifuge. All subjects answered the overtraining questionnaire proposed by the French Society for Sports Medicine. RESULTS: The best correlate of maximal power output (Wmax) was whole blood viscosity (r=-0.383, p<0.001). The stepwise regression analysis only selected Hct as W170 determinant (r=-0.66, p<0.001). Similarly the best determinant of VO2max, expressed as a percentage of theoretical values, was Hct (r=-0.462, p=0.01). Hct/viscosity ratio (Hct/eta), a proposed index of Hct's positive influence on O2 transfer to tissues, was positively correlated to Wmax expressed as a percentage of theoretical values (r=0.487, p=0.02). The overtraining score was correlated to plasma viscosity (r=0.450, p=0.016). CONCLUSION: The best hemorheogical correlate of fitness is a low hematocrit and the best hemorheological correlate of overtraining is increased plasma viscosity.
Authors:
A Gaudard; E Varlet-Marie; F Bressolle; J Mercier; J-F Brun
Related Documents :
18971378 - Multiple regulatory steps control mammalian nonmuscle myosin ii assembly in live cells.
20965948 - Exercise improves hemodynamic profiles and increases red blood cell concentrations of p...
21888528 - Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondria...
6128108 - Some functional and structural properties of bufus paracnemis and pipa pipae hemoglobins.
23765348 - Influence of dietary nitrate supplementation on exercise tolerance and performance.
9458908 - Underestimation of plasma volume changes in humans by hematocrit/hemoglobin method.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  28     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2003  
Date Detail:
Created Date:  2003-05-30     Completed Date:  2003-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  161-73     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacocinétique clinique, Faculté de Pharmacie, BP 14491, Université Montpellier I, 34093 Montpellier Cédex 5, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Viscosity
Body Composition
Cumulative Trauma Disorders / blood,  physiopathology
Electric Impedance
Erythrocyte Aggregation
Exercise
Exercise Test
Exercise Tolerance
Ferritins / blood
Fibrinogen / analysis
Hand Strength
Hematocrit*
Hemorheology*
Humans
Male
Oxygen Consumption
Physical Fitness / physiology*
Plethysmography, Impedance
Questionnaires
Sports / physiology*
Chemical
Reg. No./Substance:
9001-32-5/Fibrinogen; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Is the feeling of heavy legs in overtrained athletes related to impaired hemorheology?
Next Document:  The importance of angiogenesis in the interaction between polymeric biomaterials and surrounding tis...