Document Detail


Hemorheological changes in women with severe preeclampsia.
MedLine Citation:
PMID:  15272153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to determine the differences of hemorheological parameters in association to haematological tests in patients with severe preeclampsia (blood pressure (diastolic) > 100 mm Hg, blood pressure (systolic) > 180 mm Hg and proteinuria > 3 g/24 h). Blood samples of 45 primigravidas by hospital admission were studied. The control group were 45 pregnant women--age and weight matched--with normal blood pressure and without obstetric complications. We measured red cell aggregation (stasis, low shear), red cell elongation with the ectacytometer, blood cell indices (Hct, Hbg, MCV, MCHC, reticulocytes, white cells, platelets), fibrinogen haptoglobin and factor VIIIR:Ag, cholesterol and triclycerides. In comparison between patients with severe preeclampsia and normal pregnant women we found statistically elevated values of hematocrit, hemoglobin, red cell aggregation (stasis, low shear rate), MVC and factor VIIIR:Ag. Non-significant changes were observed in values of plasma viscosity, white cells, platelets, haptoglobin, MCHC, reticulocytes, triglycerides and cholesterol. The red cell deformability measured as cell elongation was statistically reduced by high shear stress application in patients with severe preeclampsia. Our results suggest that hemorheological parameters play an important role in severe preeclampsia, especially at microcirculatory regions with high shear stress such as intervillous space of placenta.
Authors:
L Heilmann; W Rath; K Pollow
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  31     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-23     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  IM    
Copyright Information:
Copyright 2004 IOS Press
Affiliation:
Department Obstetetric Gynecology, City Hospital, 65428 Rüsselsheim, Germany. dr_lothar_heilmann@yahoo.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / physiology*
Blood Viscosity
Cholesterol / blood
Erythrocyte Aggregation
Erythrocyte Deformability*
Female
Gestational Age
Hemorheology / methods*
Humans
Maternal Age
Pre-Eclampsia / blood*,  physiopathology*
Pregnancy
Proteinuria
Reference Values
Stress, Mechanical
Systole
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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