| Hemorheological changes in women with severe preeclampsia. | |
MedLine Citation:
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PMID: 15272153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the differences of hemorheological parameters in association to haematological tests in patients with severe preeclampsia (blood pressure (diastolic) > 100 mm Hg, blood pressure (systolic) > 180 mm Hg and proteinuria > 3 g/24 h). Blood samples of 45 primigravidas by hospital admission were studied. The control group were 45 pregnant women--age and weight matched--with normal blood pressure and without obstetric complications. We measured red cell aggregation (stasis, low shear), red cell elongation with the ectacytometer, blood cell indices (Hct, Hbg, MCV, MCHC, reticulocytes, white cells, platelets), fibrinogen haptoglobin and factor VIIIR:Ag, cholesterol and triclycerides. In comparison between patients with severe preeclampsia and normal pregnant women we found statistically elevated values of hematocrit, hemoglobin, red cell aggregation (stasis, low shear rate), MVC and factor VIIIR:Ag. Non-significant changes were observed in values of plasma viscosity, white cells, platelets, haptoglobin, MCHC, reticulocytes, triglycerides and cholesterol. The red cell deformability measured as cell elongation was statistically reduced by high shear stress application in patients with severe preeclampsia. Our results suggest that hemorheological parameters play an important role in severe preeclampsia, especially at microcirculatory regions with high shear stress such as intervillous space of placenta. |
Authors:
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L Heilmann; W Rath; K Pollow |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical hemorheology and microcirculation Volume: 31 ISSN: 1386-0291 ISO Abbreviation: Clin. Hemorheol. Microcirc. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-07-23 Completed Date: 2005-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9709206 Medline TA: Clin Hemorheol Microcirc Country: Netherlands |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Copyright Information:
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Copyright 2004 IOS Press |
Affiliation:
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Department Obstetetric Gynecology, City Hospital, 65428 Rüsselsheim, Germany. dr_lothar_heilmann@yahoo.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / physiology* Blood Viscosity Cholesterol / blood Erythrocyte Aggregation Erythrocyte Deformability* Female Gestational Age Hemorheology / methods* Humans Maternal Age Pre-Eclampsia / blood*, physiopathology* Pregnancy Proteinuria Reference Values Stress, Mechanical Systole Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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