Document Detail


Hemorheological abnormalities in stable angina and acute coronary syndromes.
MedLine Citation:
PMID:  18503109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathophysiological abnormalities of stable angina (SA) and acute coronary syndromes (ACS) may, in part, be promoted by fluid forces associated with local blood flow and hence by the rheological properties of blood. This study evaluated several hemorheological parameters in 16 healthy controls and in 16 SA, 18 unstable angina (UA) and 19 acute myocardial infarct (AMI) patients; all patients underwent diagnostic angiography following blood sampling. Rheological measurements included whole blood viscosity, plasma viscosity and RBC aggregation via erythrocyte sedimentation rate (ESR) and Myrenne aggregometer indices. Compared to controls, RBC aggregation was significantly elevated in all patient groups (p<0.001), with the rank being AMI>UA>SA. RBC aggregability as tested in 70 kDa dextran exceeded control in all patients. Blood viscosity values calculated at 40% Hct, plasma viscosity and yield shear stress values followed the same pattern (AMI>UA>SA>control); increases of inflammatory markers (i.e., WBC count, hs-CRP) were elevated in all patient groups in the order AMI>UA>SA. Our study thus indicates an association between hemorheological abnormalities and the severity of coronary artery disease, and suggests the merit of evaluating whether therapeutic interventions that normalize blood rheology may reduce the incidence and/or progression of coronary artery disease.
Authors:
Byoung K Lee; Azhil Durairaj; Anilkumar Mehra; Rosalinda B Wenby; Herbert J Meiselman; Tamas Alexy
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  39     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-08-20     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / blood*
Adult
Aged
Angina Pectoris / blood*
Angiography / methods
Blood Viscosity
Erythrocyte Aggregation
Female
Heart Catheterization
Hematocrit
Hemorheology / methods*
Humans
Male
Middle Aged
Stress, Mechanical
Grant Support
ID/Acronym/Agency:
HL 70595/HL/NHLBI NIH HHS; HL15722/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Clin Hemorheol Microcirc. 2009;41(1):81-2   [PMID:  19136746 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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