Document Detail


Hemopoetic organs damage syndrome in patients with chronic viral hepatitis.
MedLine Citation:
PMID:  15834181     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liver cirrhosis and hepatocellular carcinoma are the most frequent and severe complications of chronic hepatitis C. Results of recent investigations indicate that HCV persists and replicates not only in hepatic tissue, but in the other organs as well. The goal of our investigation was to determine hematological disorders during chronic HCV and HCV+HBV hepatitis, to find correlation between activity of chronic hepatitis, stage of cirrhosis, and degree of hematological disorders. We have studied patients with chronic C and B+C hepatitis (36 persons) and 77 HCV-infected persons on the stage of cirrhosis. The erythrocytes morphology was investigated using light microscope. The osmotic resistance of erythrocytes was investigated using the method of Ianovski (modification of Ribiera); the thrombocytes' ability to adhere and aggregate was studied by Rite's method. The absolute number of thrombocytes was counted by means of phase-contrast microscope. Our investigation suggests that there is no absolute correlation between chronic hepatitis C activity and hematological disorders and often the degree of extrahepatocellular disorders is higher than the degree of liver damage.
Authors:
E Vashakidze; L Kiladze; T Gegeshidze
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Georgian medical news     Volume:  -     ISSN:  1512-0112     ISO Abbreviation:  Georgian Med News     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-05-26     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101218222     Medline TA:  Georgian Med News     Country:  Georgia (Republic)    
Other Details:
Languages:  eng     Pagination:  49-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Enzyme-Linked Immunosorbent Assay
Erythrocytes / physiology
Female
Hematologic Diseases / etiology*
Hematologic Tests
Hepatitis B, Chronic / blood,  complications*,  diagnosis,  immunology
Hepatitis C, Chronic / blood,  complications*,  diagnosis,  immunology
Humans
Liver Cirrhosis / complications
Male
Middle Aged
Platelet Adhesiveness
Platelet Aggregation
Platelet Count
Viral Load

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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