Document Detail

Hemophilus endocarditis: new cases, literature review and recommendations for management.
MedLine Citation:
PMID:  302487     Owner:  NLM     Status:  MEDLINE    
Rarely is endocarditis attributed to the species of Hemophilus. Most frequently implicated are H aphrophilus and H parainfluenzae, but H influenzae also is seen. We report six cases of endocarditis due to H aphrophilus or H parainfluenzae and review the literature. Emboli to skin, lungs, kidneys, spleen, brain, and other organs are common complications, and acute glomerulonephritis and meningitis often occur. Ampicillin is the mainstay of antimicrobial therapy for patients whose isolates are sensitive to it, but the duration of antimicrobial therapy necessary for eradication of the infection is not clear. Studies of antimicrobial synergism are warranted in instances of endocarditis caused by ampicilin- or penicillin-resistant strains of Hemophilus, or when patients are allergic to penicillin; in these instances, combination antimicrobial therapy must be given when bactericidal synergism can be demonstrated. Intensive management of complications caused by embolization is crucial to patient survival.
R H Johnson; R P Kennedy; K I Marton; C Thornsberry
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  70     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1098-102     Citation Subset:  AIM; IM    
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MeSH Terms
Ampicillin / therapeutic use
Anti-Bacterial Agents / pharmacology,  therapeutic use*
Chloramphenicol / therapeutic use
Drug Therapy, Combination
Embolism / etiology
Endocarditis, Bacterial / complications,  drug therapy*
Haemophilus / drug effects,  isolation & purification
Haemophilus Infections / drug therapy*
Haemophilus influenzae / drug effects
Heart Valve Prosthesis
Intracranial Embolism and Thrombosis / etiology
Meningitis, Haemophilus / etiology
Middle Aged
Penicillins / therapeutic use
Streptomycin / therapeutic use
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Penicillins; 56-75-7/Chloramphenicol; 57-92-1/Streptomycin; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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