| Hemophagocytosis: the cause of anemia and thrombocytopenia in congenital syphilis. | |
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MedLine Citation:
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PMID: 19657997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Congenital syphilis is a rare, serious disease that continues to be a major health-care problem. The infected neonate may be asymptomatic or multiple-organ system involvement may occur. Anemia and thrombocytopenia are common hematological findings. Hemophagocytic lymphohistiocytosis (HLH) is a clinicopathological condition characterized by activation and uncontrolled nonmalignant proliferation of T lymphocytes and macrophages. The authors report an infant with congenital syphilis as a very rare cause of hemophagocytic syndrome. The reason for anemia and thrombocytopenia in congenital syphilis is not clear. The authors suggest that hemophagocytosis may play role in pathogenesis of cytopenia, particularly thrombocytopenia in patients with congenital syphilis. |
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Authors:
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Nese Yarali; Ismail Balaban; Nesibe Akyurek; Sit Ucar; Pelin Zorlu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 26 ISSN: 1521-0669 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-06 Completed Date: 2009-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: England |
Other Details:
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Languages: eng Pagination: 461-6 Citation Subset: IM |
Affiliation:
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Dr. Sami Ulus Children's Hospital, Department of Pediatrics, Division of Pediatric Hematology, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia / diagnosis, drug therapy, etiology* Female Humans Infant Lymphohistiocytosis, Hemophagocytic / diagnosis, drug therapy, etiology* Male Pregnancy Syphilis, Congenital / complications*, pathology Thrombocytopenia / diagnosis, drug therapy, etiology* Young Adult |
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