Document Detail

Hemophagocytic syndrome in classic dengue Fever.
MedLine Citation:
PMID:  22224008     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A 24-year-old previously healthy girl presented with persistent fever, headache, and jaundice. Rapid-test anti-dengue virus IgM antibody was positive but anti-dengue IgG was nonreactive, which is suggestive of primary dengue infection. There was clinical deterioration during empiric antibiotic and symptomatic therapy. Bone marrow examination demonstrated the presence of hemophagocytosis. Diagnosis of dengue fever with virus-associated hemophagocytic syndrome was made according to the diagnostic criteria of the HLH 2004 protocol of the Histiocyte Society. The patient recovered with corticosteroid therapy. A review of literature revealed only a handful of case reports that showed the evidence that this syndrome is caused by dengue virus. Our patient is an interesting case of hemophagocytic syndrome associated with classic dengue fever and contributes an additional case to the existing literature on this topic. This case highlights the need for increased awareness even in infections not typically associated with hemophagocytic syndrome.
Sayantan Ray; Supratip Kundu; Manjari Saha; Prantar Chakrabarti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of global infectious diseases     Volume:  3     ISSN:  0974-8245     ISO Abbreviation:  J Glob Infect Dis     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-01-06     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101521436     Medline TA:  J Glob Infect Dis     Country:  India    
Other Details:
Languages:  eng     Pagination:  399-401     Citation Subset:  -    
Department of Medicine, Medical College and Hospital, West Bengal, India.
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