Document Detail

Hemophagocytic Syndrome and Inflammatory Myopathy with Abundant Macrophages in a Patient with Adult-onset Still's Disease.
MedLine Citation:
PMID:  25318809     Owner:  NLM     Status:  In-Data-Review    
We herein describe a 71-year-old woman with adult-onset Still's disease (AOSD) who developed fever, myalgia, and pancytopenia. The bone marrow aspiration and muscle biopsy revealed hemophagocytic syndrome (HPS) and inflammatory myopathy with abundant macrophages (IMAM). Immunostained specimens were positive for expression of retinoic acid-inducible gene-I (RIG-I), which recognizes viral RNA in infiltrated mononuclear cells as well as muscle tissues. These findings suggest that RIG-I may be involved in induction of HPS and IMAM in AOSD.
Masataka Umeda; Tomoki Origuchi; Keita Fujikawa; Tomohiro Koga; Akinari Mizokami; Yoshikazu Nakashima; Takahisa Suzuki; Akitomo Okada; Shin-Ya Kawashiri; Kunihiro Ichinose; Mami Tamai; Satoshi Yamasaki; Hideki Nakamura; Atsushi Kawakami; Katsumi Eguchi
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Publication Detail:
Type:  Journal Article     Date:  2014-10-15
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  53     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2014  
Date Detail:
Created Date:  2014-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2385-9     Citation Subset:  IM    
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