| Hemoperfusion with a polymyxin B fiber column decreases clotting activity. | |
| | |
MedLine Citation:
|
PMID: 19954477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated whether hemoperfusion with a polymyxin B column (DHP-PMX) was able to improve coagulation abnormalities in patients with sepsis. Sixteen patients with sepsis were enrolled in the study. They all had signs of systemic inflammatory response syndrome due to infection and a mean arterial blood pressure > or =65mm Hg (irrespective of the use of catecholamines). A thermodilution catheter was inserted prior to DHP-PMX for intravenous infusion, and DHP-PMX was performed twice within 24 h for 3 h each time. Circulating levels of thrombin-antithrombin complex (TAT), plasmin-alpha2 plasmin inhibitor complex (PIC), the TAT/PIC ratio, and plasminogen activator inhibitor-1 (PAI-1) were measured six times. Before DHP-PMX, the TAT level was 24.5 +/- 8.3 ng/mL, the PIC level was 2.5 +/- 1.1 microg/mL, the TAT/PIC ratio was 13.9 +/- 3.5, and the PAI-1 level was 143.0 +/- 24.4 ng/L. The TAT level, TAT/PIC ratio, and PAI-1 were all significantly lower (P < 0.05) after 48 hr compared with before DHP-PMX, but no significant change of PIC was observed. In these patients with sepsis, fibrinolysis was inhibited by PAI-1, whereas clotting activity was significantly increased. This coagulation/fibrinolysis imbalance was improved by DHP-PMX. The present results suggest that indirect inhibition of clotting activity can be achieved in patients with sepsis through adsorption of lipopolysaccharide by DHP-PMX. |
| | |
Authors:
|
Hidehiko Kushi; Takahiro Miki; Yuichiro Sakagami; Jun Sato; Takeshi Saito; Katsuhisa Tanjoh |
Related Documents
:
|
7533897 - Significance of elevated thrombin-antithrombin iii complex and plasmin-alpha 2-plasmin ... 8192147 - Rapid improvement of coagulopathy by all-trans retinoic acid in acute promyelocytic leu... 16304877 - Use of recombinant factor viia for massive postpartum haemhorrage: case series and revi... 10582977 - Measurement of hemostatic indexes in conjunction with transcranial doppler sonography i... 20601157 - Percutaneous epicardial ablation of ventricular tachycardia after failure of endocardia... 2826847 - Relationship between natural killer activity and development of hepatocellular carcinom... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy Volume: 13 ISSN: 1744-9987 ISO Abbreviation: Ther Apher Dial Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-03 Completed Date: 2010-02-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101181252 Medline TA: Ther Apher Dial Country: Australia |
Other Details:
|
Languages: eng Pagination: 528-33 Citation Subset: IM |
Affiliation:
|
Department of Emergency and Critical Care Medicine, Nihon University School of Medicine, Surugadai, Chiyoda-ku, Tokyo 101-8306, Japan. hkushi@med.nihon-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adsorption Adult Aged Aged, 80 and over Blood Coagulation* Blood Coagulation Tests / methods Blood Pressure Female Fibrinolysis Hemoperfusion / methods* Humans Lipopolysaccharides / metabolism Male Middle Aged Plasminogen Activator Inhibitor 1 / blood Polymyxin B / chemistry* Prospective Studies Sepsis / therapy* Thermodilution / methods |
| Chemical | |
Reg. No./Substance:
|
0/Lipopolysaccharides; 0/Plasminogen Activator Inhibitor 1; 1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiopoietin Balance in Septic Shock Patients Treated by Direct Hemoperfusion With Polymyxin B-immob...
Next Document: Advanced glycation end products and receptor-oxidative stress system in diabetic vascular complicati...