Document Detail

Hemolytic-uremic syndrome without evidence of microangiopathic hemolytic anemia on peripheral blood smear.
MedLine Citation:
PMID:  8604470     Owner:  NLM     Status:  MEDLINE    
We report the case of an 18-year old man with hemolytic-uremic syndrome (HUS) having a classic clinical presentation and diagnostic renal pathology without evidence of microangiopathic hemolytic anemia (MAHA) by peripheral blood smear. Indirect evidence of hemolysis was suggested by mild anemia, elevation of serum lactate dehydrogenase, and examination of the patient's bone marrow. We postulate that in this case the inability to detect schistocytes in the peripheral smear reflected a low degree of hemolysis. Review of the literature revealed that evidence of fragmented erythrocytes by peripheral smear is not always present in HUS, yet this observation has received little attention. Thus, the diagnosis of HUS need not include overt evidence of MAHA as is traditionally taught.
S E Brilliant; P A Lester; A K Ohno; M J Carlon; B J Davis; H M Cushner
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  89     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-05-15     Completed Date:  1996-05-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  342-5     Citation Subset:  AIM; IM    
Department of Medicine, Madigan Army Medical Center, Tacoma, WA 98431-5000, USA.
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MeSH Terms
Erythrocytes / pathology*
Hemolytic-Uremic Syndrome / blood*,  pathology*,  physiopathology
Kidney / pathology

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