Document Detail

Hemolytic uremic syndrome in a patient with systemic sclerosis treated with cyclosporin A.
MedLine Citation:
PMID:  1357898     Owner:  NLM     Status:  MEDLINE    
The case is presented of a 48-year-old female suffering from diffuse cutaneous systemic sclerosis (diffuse scleroderma) since 8 years, who went into renal failure as part of hemolytic uremic syndrome following 3 weeks' treatment with 3.8 mg/kg cyclosporin A. Hemolytic uremic syndrome has previously been described in transplant patients receiving cyclosporin A. There are also four cases reported in the literature of renal failure developing in middle aged females with diffuse cutaneous systemic sclerosis after short-term use of low dosage cyclosporin A treatment. It is suggested, that it may be wise not to use cyclosporin A to this category of patients, in which it can not be ruled out, that even a low dose therapy may trigger the rapid onset of scleroderma renal crisis or as in our case provoke hemolytic uremic syndrome.
H Zachariae; H E Hansen; T S Olsen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  72     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  307-9     Citation Subset:  IM    
Department of Dermatology, Marselisborg hospital, Aarhus, Denmark.
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MeSH Terms
Acute Disease
Cyclosporine / adverse effects*
Hemolytic-Uremic Syndrome / chemically induced*
Kidney / pathology
Middle Aged
Scleroderma, Systemic / drug therapy*,  pathology
Reg. No./Substance:

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