Document Detail

Hemolytic transfusion reaction after preoperative prophylactic blood transfusion for sickle cell disease in pregnancy.
MedLine Citation:
PMID:  17666632     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Preoperative transfusions are frequently given to prevent morbidity in nonpregnant patients with sickle cell disease. We describe a case of a life-threatening delayed hemolytic transfusion reaction with hyperhemolysis syndrome in pregnancy. CASE: A multigravida with sickle cell disease underwent prophylactic blood transfusion before repeat cesarean delivery. Her immediate postpartum course was uneventful, but on postoperative day number 6 she presented in grave condition with what was thought initially to be an infection versus crisis. Delayed hemolytic transfusion reaction with hyperhemolysis was ultimately diagnosed. CONCLUSION: In the gravida with sickle cell disease and known multiple red cell antibodies, blood transfusion may incur a higher risk for delayed transfusion reaction, hyperhemolysis syndrome, and possible death. Blood transfusion should be used cautiously in these patients.
Christine L Proudfit; Emad Atta; Nora M Doyle
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  110     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-06     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, and Division of Maternal Fetal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
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MeSH Terms
Anemia, Hemolytic / immunology*,  prevention & control*
Anemia, Sickle Cell / complications,  therapy*
Blood Group Incompatibility / etiology
Blood Transfusion / adverse effects*
Cesarean Section, Repeat
Postpartum Period
Pregnancy Complications, Hematologic / therapy*
Pregnancy Outcome
Pregnancy, Multiple
Preoperative Care
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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