| ON THE HEMOLYTIC PROPERTIES OF FATTY ACIDS AND THEIR RELATION TO THE CAUSATION OF TOXIC HEMOLYSIS AND PERNICIOUS ANEMIA. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 19867727 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
1. The smallest amount of the sodium soaps necessary for the complete hemolysis of 0.5 of a cubic centimeter of a 5 per cent. suspension of the red blood corpuscles of the sheep, ox, rabbit, dog, or of man, is about the same,-0.03 of a milligram in the case of the following acids: oleic, linoleic, dibromostearic, chloriodostearic, and two isomeric monobromostearic acids; in the case of erucic acid about twice as much of the soap was found to be necessary; in that of palmitic or of dihydroxystearic acid more than ten times as much. 2. The minimum hemolytic quantity of the sodium soaps of the highly unsaturated acids obtained from cod liver oil and from linseed oil is only very slightly less than that of sodium oleate. 3. It follows, therefore, from these results that hemolysis by unsaturated fatty acids is not more active in proportion to the degree to which these acids are unsaturated, nor is it diminished when the unsaturated carbon atoms are saturated by halogens. It is, on the other hand, greatly diminished when they are converted into the corresponding hydroxyl acids, which are hemolytic only to the same degree as the saturated acids. 4. The idea that toxic hemolysis, in disease, in poisoning by phosphorus or toluylene diamine, results from the liberation of specially hemolytic fatty acids from the fatty complexes of disintegrating cells is not well supported by evidence; none of the fatty acids, still less any of the fatty complexes from which these acids can be obtained in any of the organs examined, either in this work or in the work of others that has preceded it, show on analysis any evidence for the existence of fatty acids more toxic than the common oleic acid which is constantly being set free by hydrolysis from common fat in health. |
| | |
Authors:
|
W F McPhedran |
Related Documents
:
|
17763147 - Interaction study of paracetamol with saturated (capric) and unsaturated (oleic) fatty ... 6102557 - Effects of fatty acids on lysis of streptococcus faecalis. 16414707 - Comparative composition of fatty acids of codium decortica tum and c. flabellatum (bryo... 2072097 - Incorporation of very-long-chain fatty acids into sphingolipids of cultured neural cells. 6552847 - Studies on the kinin formation by bovine spleen acid kininogenases. 20579527 - The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of experimental medicine Volume: 18 ISSN: 0022-1007 ISO Abbreviation: J. Exp. Med. Publication Date: 1913 Nov |
Date Detail:
|
Created Date: 2010-06-23 Completed Date: 2010-06-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: United States |
Other Details:
|
Languages: eng Pagination: 527-42 Citation Subset: - |
Affiliation:
|
The Department of Pathological Chemistry of the University of Toronto, Toronto. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): J Exp Med ISSN: 0022-1007 ISSN: 1540-9538 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1913, by The Rockefeller Institute for Medical Research New York Received Day: 2 Month: 6 Year: 1913 Print publication date: Day: 1 Month: 11 Year: 1913 Volume: 18 Issue: 5 First Page: 527 Last Page: 542 ID: 2125097 PubMed Id: 19867727 |
| ON THE HEMOLYTIC PROPERTIES OF FATTY ACIDS AND THEIR RELATION TO THE CAUSATION OF TOXIC HEMOLYSIS AND PERNICIOUS ANEMIA | |
| William Fletcher McPhedran | |
| From The Department of Pathological Chemistry of the University of Toronto, Toronto. |
|
Article Categories:
|
|
Previous Document: THE PURINES AND PURINE METABOLISM OF SOME TUMORS IN DOMESTIC ANIMALS.
Next Document: PNEUMONIC LESIONS CAUSED BY BACILLUS MEGATHERIUM.