| Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy. | |
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MedLine Citation:
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PMID: 20122559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 66-year-old woman was referred for further evaluation and treatment of normocytic and normochromic anemia with hemoglobin level of 8.6 g/dL. A peripheral blood smear showed fragmented erythrocytes. The patient was then referred to the department of cardiology because of systolic murmur, ECG abnormality, and red cell fragmentation. Transthoracic echocardiography revealed hypertrophic cardiomyopathy with particularly increased interventricular septal thickness of 24 mm and a hyperkinetic wall motion, resulting in marked obstruction to left ventricular outflow tract (pressure gradient of 200 mmHg). Mitral regurgitation due to systolic anterior motion of the mitral valve leaflets was also seen. The cause of anemia was thought to be mechanical intravascular hemolysis due to left ventricular outflow tract obstruction and mitral regurgitation. She was treated with atenolol and the class Ia antiarrhythmic drug cibenzoline to relieve the outflow tract obstruction, and the pressure gradient was reduced to 70 mmHg. After 3 months of treatment, her hemoglobin level had increased to 11.4 g/dL without additional treatment for anemia. |
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Authors:
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Toru Kubo; Hiroaki Kitaoka; Yasunobu Terauchi; Shinjiro Tamura; Makoto Okawa; Naohito Yamasaki; Toshikazu Yabe; Yoshinori L Doi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-05-09 |
Journal Detail:
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Title: Journal of cardiology Volume: 55 ISSN: 0914-5087 ISO Abbreviation: J Cardiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-08-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Copyright Information:
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2009 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine and Geriatrics, Kochi Medical School, Kochi, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anemia, Hemolytic / etiology* Anti-Arrhythmia Agents / therapeutic use Atenolol / therapeutic use Cardiomyopathy, Hypertrophic / complications*, diagnosis Echocardiography Female Humans Imidazoles / therapeutic use Mitral Valve Insufficiency / etiology Ventricular Outflow Obstruction / etiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Imidazoles; 29122-68-7/Atenolol; 53267-01-9/cifenline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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