Document Detail

Hemolytic anemia caused by pyrimidine 5'-nucleotidase (P5N) deficiency 15 years later. Apropos of 2 new cases of hereditary deficit and another one of lead poisoning
MedLine Citation:
PMID:  2558262     Owner:  NLM     Status:  MEDLINE    
Congenital pyrimidin 5'nucleotidase deficiency manifests as hemolytic anemia with basophilic stippling. In lead poisoning, anemia, basophilic stippling and inhibition of erythrocyte pyrimidin 5' deficiency are also observed. In the present work, we report two cases of hemolytic anemia secondary to congenital deficiency of pyrimidin 5' nucleotidase and another case secondary to lead poisoning. Since 1974, when pyrimidin 5' nucleotidase deficiency was isolated, is known that hemolysis is related to the accumulation of pyrimidin nucleotides within the erythrocytes that behave as metabolic inhibitors. However, the precise metabolic process whose inhibition leads to the shortening of erythrocytes half life has not been elucidated yet.
F J de la Serna; F Gilsanz; P Ricard; A Urrutia
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Medicina clínica     Volume:  93     ISSN:  0025-7753     ISO Abbreviation:  Med Clin (Barc)     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376377     Medline TA:  Med Clin (Barc)     Country:  SPAIN    
Other Details:
Languages:  spa     Pagination:  380-2     Citation Subset:  IM    
Vernacular Title:
Anemia hemolítica por déficit de pirimidina 5'nucleotidasa (P5N) 15 años después. A propósito de 2 nuevos casos de déficit hereditario y otro de intoxicación por plomo.
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MeSH Terms
5'-Nucleotidase / deficiency*
Anemia, Hemolytic / chemically induced,  enzymology,  etiology*,  genetics
Lead Poisoning / complications*
Middle Aged
Time Factors
Reg. No./Substance:

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