| Hemolytic disease of the newborn associated with anti-Jra alloimmunization in a twin pregnancy: the first case report in Korea. | |
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MedLine Citation:
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PMID: 20890084 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Jr(a) is a high-frequency antigen found in all ethnic groups. However, the clinical significance of the anti-Jr(a) antibody has remained controversial. Most studies have reported mild hemolytic disease of the newborn and fetus (HDNF) in Jr(a)-positive patients. Recently, fatal cases of HDNF have also been reported. We report the first case of HDNF caused by anti-Jr(a) alloimmunization in twins in Korea. A 33-yr-old nulliparous woman with no history of transfusion or amniocentesis was admitted at the 32nd week of gestation because of vaginal bleeding caused by placenta previa. Anti-Jr(a) antibodies were detected in a routine laboratory examination. An emergency cesarean section was performed at the 34th week of gestation, and 2 premature infant twins were delivered. Laboratory examination showed positive direct antiglobulin test and Jr(a+) phenotype in the red blood cells and the presence of anti-Jr(a) antibodies in the serum in both neonates. The infants underwent phototherapy for neonatal jaundice; this was followed by conservative management. They showed no further complications and were discharged on the 19th postpartum day. Preparative management to ensure the availability of Jr(a-) blood, via autologous donation, and close fetal monitoring must be performed even in cases of first pregnancy in Jr(a-) women. |
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Authors:
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Hyungsuk Kim; Min-Jeong Park; Tae-Jung Sung; Ji Seon Choi; Jungwon Hyun; Kyoung Un Park; Kyou-Sup Han |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Korean journal of laboratory medicine Volume: 30 ISSN: 1598-6535 ISO Abbreviation: Korean J Lab Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101322822 Medline TA: Korean J Lab Med Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 511-5 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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