| Hemolysis and survival of autologous red blood cells salvaged after cemented and uncemented total hip arthroplasty. | |
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MedLine Citation:
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PMID: 20396680 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Autotransfusion is widely used after total hip arthroplasty (THA), but there are concerns about damage of red blood cells (RBCs) collected after surgery. In this study, we wanted to determine the damage and survival of RBCs salvaged after cemented THA and after uncemented THA and to compare the results. In this prospective study of 60 patients-30 who underwent cemented THA and 30 who underwent uncemented THA-postoperative autotransfusion systems (BIODREN; B.E.R.C.O., Modena, Italy) were used. Levels of potassium and free hemoglobin in the postoperative blood samples were analyzed. Before transfusion, salvaged RBCs were labeled with radioactive chromium-51, and their survival was measured. In blood salvaged after cemented THA, medium potassium level was 4.1 mmol/L (range, 3.2-5.6 mmol/L), and mean free hemoglobin level was 327 mg% (range, 120-410 mg%). In blood salvaged after uncemented THA, mean potassium level was 4.2 mmol/L (range, 3.1-5.5 mmol/L), and mean free hemoglobin level was 296 mg% (range, 130-402 mg%). In the cemented group, RBC survival was 73% at 48 hours after transfusion (range, 61%-79%), and mean time from 100% activity to 50% activity was 21 days (range, 14.2-28.2 days). In the uncemented group, RBC survival was 75% at 48 hours after transfusion (range, 68%-82%), and mean time from 100% to 50% activity of radio-labeled RBCs was 22 days (range, 16.2-29.4 days). There were no statistically significant differences in potassium levels, free hemoglobin levels, or RBC survival between the cemented and uncemented groups. Blood salvaged after surgery was not significantly damaged. Our study results confirmed that washing blood collected after surgery is not necessary. Not washing this blood is safe and decreases allogeneic transfusion in orthopedic procedures. |
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Authors:
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Branko Tripkovic; Katarina Sakic; Sanja Jakovina; Sime Sakic; Zlatko Hrgovic |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: American journal of orthopedics (Belle Mead, N.J.) Volume: 39 ISSN: 1934-3418 ISO Abbreviation: Am J. Orthop. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9502918 Medline TA: Am J Orthop (Belle Mead NJ) Country: United States |
Other Details:
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Languages: eng Pagination: 76-9 Citation Subset: IM |
Affiliation:
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Orthopaedic Surgery Department, University Hospital Zagreb, Croatia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arthroplasty, Replacement, Hip* Blood Cell Count Blood Loss, Surgical Blood Transfusion, Autologous* Bone Cements / adverse effects* Cementation Chromium Radioisotopes / diagnostic use Erythrocyte Aging / drug effects* Hemoglobins / analysis Hemolysis / drug effects*, physiology Humans Polymethacrylic Acids / adverse effects* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Bone Cements; 0/Chromium Radioisotopes; 0/Hemoglobins; 0/Polymethacrylic Acids; 25087-26-7/polymethacrylic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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