Document Detail


Hemolysis-associated priapism in sickle cell disease.
MedLine Citation:
PMID:  15985542     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Priapism, although uncommon in the general population, is one of the many serious complications associated with sickle cell disease (SCD). Few studies have described the clinical and hematologic characteristics of individuals with priapism and SCD. Using data from the Cooperative Study for Sickle Cell Disease, we assembled 273 case subjects with priapism and 979 control subjects. Case subjects, compared with control subjects, had significantly lower levels of hemoglobin; higher levels of lactate dehydrogenase, bilirubin, and aspartate aminotransferase; and higher reticulocyte, white blood cell, and platelet counts. These findings suggest an association of priapism with increased hemolysis. Hemolysis decreases the availability of circulating nitric oxide, which plays an important role in erectile function.
Authors:
Vikki G Nolan; Diego F Wyszynski; Lindsay A Farrer; Martin H Steinberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2005-06-28
Journal Detail:
Title:  Blood     Volume:  106     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-20     Completed Date:  2005-11-30     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3264-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Boston University School of Medicine, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Anemia, Sickle Cell / complications*,  physiopathology*
Hemolysis / physiology*
Humans
Male
Phenotype
Priapism / complications*,  physiopathology*
Grant Support
ID/Acronym/Agency:
HL R01 68970/HL/NHLBI NIH HHS; R01 HL068970-04/HL/NHLBI NIH HHS; T32 HL007501/HL/NHLBI NIH HHS
Comments/Corrections

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