Document Detail


Hemolysate-induced release of prostaglandinlike substances from the canine cerebral arteries.
MedLine Citation:
PMID:  3975836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The release of prostaglandinlike substances from canine pial arteries that was induced by exposure of the pial arteries to red blood cell hemolysate was estimated by using a superfusion technique for prostaglandin bioassay. The assay organs used were strips of rat stomach for prostaglandin E2- or prostaglandin F2 alpha-like substances, strips of dog coronary artery for prostaglandin I2-like substance, and strips of dog ileum for prostaglandin F2 alpha-like substance. The substances released from the canine pial arteries induced contractions in rat stomach strips and relaxations in canine coronary arterial strips, whereas they did not induce any response in canine ileal strips. The equivalent prostaglandin E2 doses for the contractions of the rat stomach strips and the equivalent prostaglandin I2 doses for the relaxations of the canine coronary arterial strips were 125.2 +/- 19.4 (n = 8) and 59.5 +/- 16.4 (n = 6) pmol/g wet wt +/- SEM, respectively.
Authors:
S Okamoto; H Handa; Y Handa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  23     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-04-25     Completed Date:  1985-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Arteries / metabolism*
Coronary Vessels / drug effects,  physiology
Dogs
Erythrocytes / physiology*
Female
Ileum / drug effects,  physiology
Male
Prostaglandins / metabolism*,  pharmacology
Stomach / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Prostaglandins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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