Document Detail

Hemoglobin variability does not predict mortality in peritoneal dialysis patients.
MedLine Citation:
PMID:  22483431     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hemoglobin variability in hemodialysis patients treated with erythropoiesis-stimulating agents has been used to evaluate mortality and comorbidity. Different outcomes have been reported in American and European hemodialysis patients. There are, however, few studies of the effects of hemoglobin variability in peritoneal dialysis patients.
METHODS: We investigated hemoglobin variability in 363 peritoneal dialysis patients over 2 years to evaluate mortality and the association with comorbidity, peritonitis, and hospitalization. The hemoglobin of all patients selected for the study had been monitored for at least 6 months (April 2008 to September 2008). We assessed hemoglobin variability as fluctuations from the target hemoglobin level (11-12.5 g/dL). We defined the following 6 patient groups on the basis of hemoglobin patterns: consistently low (< 11 g/dL), consistently target range (11-12.5 g/dL), consistently high (> 12.5 g/dL), low-amplitude fluctuation with low hemoglobin levels, low-amplitude fluctuation with high hemoglobin levels, and high amplitude fluctuation.
RESULTS: Only 2% of patients maintained a stable hemoglobin level within the target range and 46.8% of patients exhibited consistently low hemoglobin levels. After 2 years of observation, there was no difference in mortality as assessed by Kaplan-Meier analysis. There were also no differences in peritonitis and hospitalization between the 6 groups. However, the length of hospital stay was longer in the high amplitude fluctuation group (p = 0.008).
CONCLUSION: Hemoglobin variability does not predict mortality in peritoneal dialysis patients.
Ho-Ching Chen; Kuan-Hsing Chen; Yu-Jr Lin; Chee-Jen Chang; Ya-Chung Tian; Chih-Wei Yang; Cheng-Chieh Hung
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chang Gung medical journal     Volume:  35     ISSN:  2309-835X     ISO Abbreviation:  Chang Gung Med J     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-08-20     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  101088034     Medline TA:  Chang Gung Med J     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  79-87     Citation Subset:  IM    
Department of Nephrology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyun, Taiwan.
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MeSH Terms
Follow-Up Studies
Hemoglobins / metabolism*
Hospitalization / statistics & numerical data
Kaplan-Meier Estimate
Middle Aged
Peritoneal Dialysis / mortality*
Retrospective Studies
Reg. No./Substance:

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